参芪益肠汤对胃癌根治术后癌因性疲劳及其他各项指标的影响

Effect of Shenqi Yichang decoction on cancer-related fatigue and other indicators after radical treatment of gastric cancer

目的:观察参芪益肠汤对胃癌根治术后患者的癌因性疲劳、生活质量、胃肠功能及免疫功能的影响。方法:选取接受胃癌根治术的患者90例,采用回顾性研究,按照术后是否使用参芪益肠汤分为治疗组和对照组,每组各45例。对照组予以西医常规对症支持治疗,治疗组在对照组基础上加用参芪益肠汤治疗,疗程均为4周。比较2组治疗前后Piper疲乏量表评分、癌症患者生命质量测定量表(FACT-G)评分、淋巴细胞亚群指标[CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、自然杀伤细胞(NK)]水平及治疗后胃肠功能恢复情况。结果:2组治疗后Piper疲乏量表评分、FACT-G各项指标评分和淋巴细胞亚群指标水平均较治疗前改善,且治疗组优于对照组(P<0.05或P<0.01)。治疗组肠鸣音恢复时间、肛门排气时间、排便时间均短于对照组,胃管总引流量较对照组减少,差异均有统计学意义(P<0.01)。结论:参芪益肠汤可明显改善胃癌根治术后患者癌因性疲劳症状,促进胃肠功能恢复,增强机体免疫功能,提高生活质量。

Objective:To investigate the effect of Shenqi Yichang decoction on cancer-related fatigue,quality of life,gastrointestinal function,and immune function in patients after radical treatment of gastric cancer.Methods:A retrospective analysis was performed for 90 patients who underwent radical treatment of gastric cancer,and according to whether Shenqi Yichang decoction was used after treatment,the patients were divided into treatment group and control group,with 45 patients in each group.The patients in the control group were given conventional Western medicine symptomatic/supportive treatment,and those in the treatment group were given Shenqi Yichang decoction in addition to the treatment in the control group;the course of treatment was 4 weeks for both groups.The two groups were compared in terms of Piper Fatigue Scale score,Functional Assessment of Cancer Therapy-General(FACT-G)score,and levels of lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and NK)before and after treatment,as well as the recovery of gastrointestinal function after treatment.Results:After treatment,both groups had significant improvements in Piper Fatigue Scale score,FACT-G score,and the levels of lymphocyte subsets,and the treatment group had significantly better improvements than the control group(P<0.05 or P<0.01).Compared with the control group,the treatment group had significantly shorter time to first bowel sound,time to first flatus,and time to first defecation and a significantly lower total stomach tube drainage volume(P<0.01).Conclusion:For the patients after radical treatment of gastric cancer,Shenqi Yichang decoction can significantly improve the symptoms of cancer-related fatigue,promote the recovery of gastrointestinal function,enhance the body’s immune function,and improve quality of life.