益生菌在自闭症中的疗效及对氧化应激状态的影响观察

Observation on the Effect of Probiotics in Patients With Autism and Influence for Oxidative Stress State

目的探究及观察益生菌在自闭症中的疗效及对氧化应激状态的影响。方法将2019年9月—2021年9月的80例自闭症患儿根据随机数字表法分为对照组40例和观察组40例。对照组进行常规自闭症治疗,观察组则在对照组的基础上加用益生菌。比较两组的临床总有效率、治疗前后的儿童孤独症评定量表(childhood autism rating scale,CARS)、儿童生存质量普适性核心量表(pediatric quality of life inventory version 4.0 generic core scales,PedsQL 4.0)及氧化应激指标[血清谷胱甘肽(glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)及一氧化氮(nitric oxide,NO)]。结果治疗3个月及6个月观察组的临床总有效率显著高于对照组,差异有统计学意义(P<0.05),治疗前两组的CARS量表、PedsQL 4.0量表及血清氧化应激指标比较,差异无统计学意义(P>0.05),治疗3个月及6个月后观察组的CARS量表及PedsQL 4.0量表评分显著优于对照组,血清GSH及SOD显著高于对照组,血清NO显著低于对照组,差异有统计学意义(P<0.05)。结论益生菌在自闭症中的疗效较好,且可显著改善患儿的氧化应激状态,因此在自闭症患儿中的应用价值较高。

Objective To investigate and observe the effect of probiotics in patients with autism and influence for oxidative stress state.Methods A total of 80 children with autism from September 2019 to September 2021 were divided into the control group 40 cases and the observation group 40 cases by random number table method.The control group was treated with routine treatment of autism,the observation group was treated with probiotics on the treatment of control group.Then the total effective rates,childhood autism rating scale(CARS),pediatric quality of life inventory version 4.0 generic core scales(PedsQL 4.0)and oxidative stress indexes[serum glutathione(GSH),superoxide dismutase(SOD)and nitric oxide(NO)]before and after the treatment of two groups were compared.Results After 3 months and 6 months of treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the CARS scale,PedsQL 4.0 scale and serum oxidative stress indexes between the two groups before treatment(P>0.05).After 3 months and 6 months of treatment,the scores of CARS and PedsQL 4.0 in the observation group were significantly better than those in the control group,serum GSH and SOD were significantly higher than those in the control group,and serum NO was significantly lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion The effect of probiotics in patients with autism is better,and it can significantly improve the oxidative stress state of children,so its application value in the children with autism is higher.