子宫内膜异位症患者腹腔镜术后血清炎性因子、基础内分泌指标变化及临床意义

Changes and clinical significance of serum inflammatory factors and basic endocrine indicators in patients with endometriosis after laparo-scopic surgery

目的探讨子宫内膜异位症患者腹腔镜术后血清炎性因子、基础内分泌指标变化及临床意义。方法选取2020年6月至2022年2月本院接诊的子宫内膜异位症患者70例为研究对象,按照随机数表法,分为研究组与对照组,每组35例。对照组行开腹手术,研究组行腹腔镜术。使用酶联免疫法测定所有患者手术前及手术后24 h肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、雌二醇(E_(2))、黄体生成素(LH)、卵泡刺激素(FSH)水平,并对结果进行比较。结果术前,两组患者IL-6、TNF-α水平相比,差异无统计学意义(P>0.05);术后24 h,研究组患者的IL-6、TNF-α水平明显低于对照组,差异有统计学意义(P<0.05);术前,两组患者E_(2)、FSH、LH水平相比,差异无统计学意义(P>0.05);术后24 h,研究组患者的E_(2)水平明显高于对照组,FSH、LH水平明显低于对照组,差异有统计学意义(P<0.05)。结论子宫内膜异位症患者应用腹腔镜术治疗,可有效减少炎症因子水平,同时还能明显改善基础内分泌水平,值得于临床推广应用。

Objective To investigate the changes of serum inflammatory factors and basic endocrine indicators in patients with endometriosis after laparoscopic surgery and their clinical significance. Methods Seventy patients with endometriosis admitted into our hospital from June 2020to February 2022 were selected as the research objects. According to the random number table method, they were divided into the research group and the control group, with 35 cases in each group. The control group received laparotomy and the study group received laparoscopy. The levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), estradiol(E), luteinizing hormone(LH) and follicle stimulating hormone(FSH) were measured by enzyme-linked immunosorbent assay before and 24 hours after surgery in all patients, and the results were compared. Results Before operation,there was no significant difference in the levels of IL-6 and TNF-α between the two groups(P>0.05). At 24h after operation, the levels of IL-6 and TNF-α in the study group were significantly lower than those in the control group(P<0.05). There was no significant difference in E, FSH and LH levels between the two groups before operation(P>0.05). At 24h after operation, the level of Ein the study group was significantly higher than that in the control group, and the levels of FSH and LH were significantly lower than those in the control group, with a statistically significant difference( P<0.05). Conclusion Laparoscopic surgery can effectively reduce inflammatory factors and significantly improve the basic endocrine level in patients with endometriosis, which is worthy of clinical application.