内皮源性细胞外囊泡对ARDS调控机制的研究进展

Research progress on the regulatory mechanism of endothelial derived extracellular vesicles in acute respiratory distress syndrome

急性呼吸窘迫综合征(ARDS)是由肺内外源性多种损伤因素引起的一类临床综合征,其发病率及病死率一直居高不下。近年来研究表明,内皮衍生的细胞外囊泡是病理信号转导的重要媒介,在ARDS发生发展及预后转归中发挥重要调控作用,现就内皮来源的细胞外囊泡在ARDS中的调控机制进行综述。

Acute respiratory distress syndrome(ARDS)is a clinical syndrome caused by a variety of internal and external injury factors in the lung,and its morbidity and mortality have remained stubbornly high.Recent studies have shown that endothelial-derived extracellular vesicles are an important mediator of pathological signal transduction and play an important regulatory role in the occurrence,development and prognosis of ARDS.Now our paper reviewed the regulatory mechanism of endothelial-derived extracellular vesicles in ARDS.