甘草内生菌研究概况

Research Progress on Endophytes from Glycyrrhiza uralensis

甘草内生菌能够产生与宿主植物相同、相似或全新的活性代谢物。采用内生菌发酵法生产甘草次生代谢物对可持续利用甘草资源及筛选新型活性代谢产物具有重要意义。在过去的几十年,尽管人们对甘草内生菌多样性、分离和鉴定、药理作用、次生代谢产物等方面进行了研究,并取得了一定的成果,但还远远不能满足生产的需要,甘草内生菌作为微生物资源是天然产物的重要来源。本研究综述了甘草内生菌及其次生代谢产物的相关研究,归纳出甘草内生菌可产甘草苷、甘草次酸、甘草素等次生代谢产物,并针对甘草内生菌次生代谢产物研究中存在的问题进行了展望,为合理利用甘草内生菌及进一步开发应用提供参考。

Endophytes isolated from Glycyrrhiza uralensis have the potential to produce the same,similar or new active metabolites as the host plants.Secondary metabolites of Glycyrrhiza uralensis produced by fermentation with endophytes are not only important for sustainable utilization of Glycyrrhiza uralensis resources but also significant for screening new metabolites.In the past several decades,although the diversity,isolation and identification,pharmacological action,secondary metabolites and other aspects of endophytes from Glycyrrhiza uralensis have been studied and some achievements have been obtained,it is far from meeting the needs of production.As a microbial resource,endophytes from Glycyrrhiza uralensis are an important source of natural products.The study reviewed the research on endophytes from Glycyrrhiza uralensis and their metabolites,and summarized that endophytes from Glycyrrhiza uralensis could produce liquiritin,glycyrrhetinic acid,liquiritigenin and other secondary metabolites.Meanwhile,according to the problems in the research on secondary metabolites of endophytes from Glycyrrhiza uralensis,the study discussed the prospect and provided certain reference for the rational utilization of endophytes from Glycyrrhiza uralensis.