摘要
Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of urolithiasis.Objective:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ABC.Methods:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking water.Group I acted as the standard control group and was given unlimited access to conventional rat food and water.Group II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 days.Group III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the vehicle.Aavarai Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative regimen.From the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative regimen.All groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were determined.ABC treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic activity.Conclusion:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.
