近红外光刺激响应材料调控离子通道功能研究进展

Progress of regulating ion channel function based on near-infrared light stimuli-responsive materials

离子通道作为细胞膜上的一种跨膜受体蛋白,可介导离子被动流入/流出细胞或细胞内细胞器,从而控制细胞质/细胞器内离子浓度、膜电位和细胞体积。离子通道还参与肌肉收缩、突触传递、信号转导等基本生理过程。离子通道结构或功能异常会导致许多疾病发生,如心血管疾病(心绞痛、高血压、心律失常)、代谢紊乱(糖尿病)、神经系统疾病(疼痛、中风、癫痫)和癌症。因此,通过调控离子通道功能治疗这些疾病具有重要意义。基于近红外光深层组织穿透性的优势,通过近红外光刺激响应材料精准且时空地调控离子通道开关,实现对细胞内信号通路的精准调控,为治疗相关疾病提供了新策略。本文综述了近红外光刺激响应材料调控离子通道功能研究进展,并且对其今后的发展方向进行展望。

As a transmembrane receptor protein,ion channels mediate passive influx/efflux of essential ions into/from the cell or intracellular organelles,thereby controlling the cytoplasmic/intraorganellar ion concentrations,membrane potential,and cell volume.Ion channels are also involved in basic physiological processes such as muscle contraction,synaptic transmission,and signal transduction.Abnormalities in the structure or function of ion channels can lead to many diseases,such as cardiovascular diseases(angina pectoris,hypertension,arrhythmia),metabolic disorders(diabetes),and nervous system diseases(pain,stroke,epilepsy),and cancer.Therefore,it is of great significance in the treatment of ion channel-related diseases by regulating the function of ion channels.Based on the advantages of deep tissue penetration of near-infrared light,ion channels are precisely and temporally regulated by applying near-infrared light stimulation-responsive materials.It can realize the regulation of intracellular signaling pathways and provide new strategies for the treatment of related diseases.Here,this review concludes the progress of regulating ion channel function based on near-infrared light stimuli-responsive materials and presents its future development.