光/磁热Fe_(2)SiO_(4)/Fe_(3)O_(4)双相生物陶瓷及其复合电纺丝膜制备及抗菌性能研究

Photo/Magnetic Thermal Fe_(2)SiO_(4)/Fe_(3)O_(4) Biphasic Bioceramic and Its Composite Electrospun Membrane:Preparation and Antibacterial

兼具抗菌和组织修复活性的生物材料在再生医学领域具有广阔的应用前景。以光热和磁热为基础的热疗技术都具有抗菌作用,但光的穿透能力有限,磁热试剂的热转换效率较低,限制了其在生物医学领域的应用。本研究合成了Fe_(2)SiO_(4)/Fe_(3)O_(4)双相复合生物陶瓷粉体,不仅同时具有良好的光热和磁热效应,还能有效释放活性的铁和硅酸根离子。用陶瓷粉体与明胶/聚己内酯复合制备的电纺丝膜不仅具有良好的细胞相容性,而且具有光热和磁热效应。复合膜在相对温和的条件下近红外光(808 nm,0.36 W·cm^(–2))与交变磁场(506 k Hz,837 A·m^(–1))同时处理15 min后,与单独近红外光或磁场热处理相比,具有更强的细菌抑制活性。因此,这种集光热、磁热功能于一体且具有细胞相容性的Fe-Si基生物陶瓷及其复合材料在再生医学领域具有潜在的应用前景。

Biomaterials with both antibacterial and tissue repair activity have promising applications in the field of regenerative medicine.Both photothermal and magnetothermal-based techniques have antimicrobial effects,but the limited penetration capacity of light and the low thermal conversion efficiency of magnetothermal reagents limit their applications in biomedical fields.Here,we synthesized Fe_(2)SiO_(4)/Fe_(3)O_(4) biphasic composite bioceramic powders,which not only display good photothermal and magnetothermal effects,but also effectively release active Fe and silicate ions,and prepared electrospun membranes by combining ceramic powders with gelatin/polycaprolactone,which not only exhibit good cytocompatibility,but also,importantly,possess both photothermal and magnetothermal properties.The composite membranes,under conditions of being irradiated with near-infrared light (808 nm,0.36 W·cm^(–2)) and placed in alternating magnetic field (506 k Hz,837 A·m^(–1)) for 15 min simultaneously,are able to inhibit bacterial activity more effectively than the thermal treatment with near-infrared light or magnetic field alone.Therefore,this Fe-Si-based bioceramic and its composite material with photothermal,magnetothermal,antimicrobial,and biocompatible properties,have potential application in the field of regenerative medicine.