摘要
设计合成了一种新型叔胺方酰胺型有机催化剂,并将其应用于乙酰丙酮与硝基烯烃的不对称Michael加成反应。在无溶剂条件下,催化剂使用量为0.5 mol%时,催化体系表现出良好的活性和立体选择性,得到了一系列用于合成和医药的重要手性化合物,收率最高95%,对映选择性最高97% ee 。
A novel tertiary amine squaramide type organocatalyst was successfully designed and synthesized,and applied to the asymmetric Michael addition reaction between acetylacetone and nitroolefins.Under solvent-free conditions,the catalyst system showed good activity and enantioselectivity when the catalyst loading was 0.5 mol%.A series of chiral compounds useful in synthesis and medicine were obtained in high to 95%yield with up to 97% ee .
作者
马志伟
陈晓培
刘志景
王川川
陶京朝
MA Zhi-wei;CHEN Xiao-pei;LIU Zhi-jing;WANG Chuan-chuan;TAO Jing-chao(Faculty of Science,Henan University of Animal Husbandry and Economy,Zhengzhou 450046,China;College of Chemistry,Zhengzhou University,Zhengzhou 450001,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2022年第10期2571-2575,共5页
Chemical Research and Application
基金
河南省自然科学基金项目(202300410188)资助
河南省高等学校青年骨干教师培养计划项目(2021GGJS173)资助
河南牧业经济学院科研项目(XKYCXJJ2020002,2018HNUAHEDF014)资助。
