二十八烷醇微乳液的制备与微观模拟

Preparation and microscopic simulation of octacosanol microemulsion

通过拟三元相图确定微乳区,电导率分析微乳类型耗散粒子动力学(DPD)模拟微乳体系,制备高负载量的二十八烷醇微乳液。结果表明:以吐温-80、乙醇(质量比5∶18)作为混合表面活性剂,混合表面活性剂与油相的质量比≥57.5∶1时,可形成水包油型微乳。电导率测定结果显示,以空白微乳质量为基准,水的质量分数<10%时,微乳体系为油包水型;水的质量分数为20%~60%时,微乳为双连续型;水的质量分数>70%时,微乳为水包油型。DPD模拟微乳体系结果显示,该微乳体系在水质量分数为10%和70%时发生相变,与实际值一致,说明所建模型准确可行。

The microemulsion region was determined by pseudo-ternary-phase diagram, the microemulsion type was analyzed by electrical conductivity, and the microemulsion system was simulated by dissipative particle dynamics(DPD) to prepare the high-loading microemulsion of octacosanol. The results showed that when Tween-80 and ethanol(mass ratio: 5 ∶18) were used as the mixed surfactant, oil-in-water microemulsion could be formed when the mass ratio of the mixed surfactant to the oil phase was ≥57.5 ∶1. The electrical conductivity measurement showed that based on the quality of the blank microemulsion, when the mass fraction of water was less than 10 %, the microemulsion system was water-in-oil type. when the mass fraction of water was between 20 % and 60 %, the microemulsion was bi-continuous. When the mass fraction of water was more than 70 %, the microemulsion was oil-in-water type. The results of DPD simulation of microemulsion system showed that phase transition occurred when the water mass fraction was 10 % and 70 %, which was consistent with the actual value, indicating that the established model was accurate and feasible.