实时剪切波弹性成像评估健康儿童甲状腺杨氏模量值的参考范围及其影响因素

Reference Range and Influencing Factors of Young's Modulus of Thyroid in Healthy Children Assessed by Real-time Shear Wave Elastography

【目的】探讨实时剪切波弹性成像(SWE)技术评估健康儿童甲状腺杨氏模量最大值(Emax)、最小值(Emin)、平均值(Emean)的参考范围及其影响因素。【方法】选取在湖南省儿童医院行SWE检查并记录相关Emax、Emin、Emean的314例健康儿童,比较健康儿童不同性别、不同年龄、左右长轴的甲状腺杨氏弹性模量值Emax、Emin、Emean的差异。【结果】314例健康儿童甲状腺杨氏模量Emax、Emin、Emean分别为(13.630±3.520)KPa、(9.160±2.927)KPa、(11.189±3.127)KPa。健康儿童不同性别、左右长轴甲状腺杨氏模量值Emax、Emin、Emean比较,差异无统计学意义(P>0.05);不同年龄健康儿童甲状腺杨氏模量值Emax、Emin、Emean比较,差异有统计学意义(P<0.05)。【结论】SWE作为一种定量、无创性检测甲状腺硬度的检查方法,依据所收集的数据能计算健康儿童甲状腺组织Emax、Emin、Emean的参考范围,但其受年龄的影响,为进一步制定儿童甲状腺正常弹性模量参考值及诊断甲状腺疾病提供参考依据。

【Objective】To explore the reference range and influencing factors of real-time shear wave ultrasonic elastography(SWE)in evaluating the maximum value(Emax),minimum value(Emin)and mean value(Emean)of Young's modulus of thyroid in healthy children.【Methods】A total of 314 healthy children in Hunan Children's Hospital who underwent SWE examination and recorded E_(max),E_(min),and E_(mean) were selected to compare the differences of thyroid Young's modulus of elasticity Emax,Emin,and Emean among healthy children of different sexes,different ages,and left and right long axes.【Results】The thyroid Young's modulus Emax,Emin,and Emean of 314 healthy children were(13.630±3.520)KPa,(9.160±2.927)KPa and(11.189±3.127)KPa,respectively.There was no significant difference in young's modulus values E_(max),E_(min),and E_(mean) of the left and right long axis thyroid of healthy children between different genders(P>0.05);The thyroid Young's modulus values Emax,Emin,and Emean of healthy children at different ages were statistically significant(P<0.05).【Conclusion】As a quantitative and non-invasive examination method for thyroid hardness,SWE can calculate the reference range of E_(max),E_(min),and E_(mean) in thyroid tissue of healthy children according to the collected data,but it is affected by age,which provides a reference basis for further formulating the reference value of normal modulus of elasticity of children's thyroid and diagnosing thyroid diseases.