脂肪干细胞在心肌损伤修复中的研究进展

Adipose derived stem cells for myocardial injury repair:a review

干细胞疗法被广泛地应用于心脏相关疾病的研究。脂肪干细胞(ADSCs)作为一种成体干细胞,易于获得和扩增,具有多向分化潜能,已被证明具有分化为心肌样细胞、血管平滑肌细胞和内皮细胞的能力,成为治疗心血管疾病成体干细胞的重要来源。此外,ADSCs分泌一系列旁分泌因子促进血管新生,减少调亡,抑制纤维化,在促进心肌损伤修复中具有巨大潜力,但是ADSCs仍然面临移植存活率低等问题。在此,重点对ADSCs的治疗机制和提高治疗效果的策略等前沿进行综述。

Stem cell therapy has been widely used in the research of heart-related diseases.Adipose-derived stem cells(ADSCs),as a kind of adult stem cells,are easily obtained and expanded,and have multi-directional differentiation potential.It has been demonstrated that ADSCs have the ability to differentiate into myocyte-like cells,vascular smooth muscle cells and endothelial cells,and became an important source of adult stem cells for the treatment of cardiovascular diseases.Furthermore,ADSCs secrete a series of paracrine factors that can promote neovascularization,reduce apoptosis,and inhibit fibrosis,and have great potential in promoting the repair of myocardial injury.But ADSCs still face the problem of low survival rate.Here,we focus on reviewing the leading edge of the ADSCs therapeutic mechanisms and strategies for improving therapeutic effectiveness.