脂肪干细胞促进慢性创面愈合的研究进展

Research progress of adipose-derived stem cells in the treatment of chronic wounds

临床上治疗创面的方法多种多样,但对于慢性创面,因存在过度炎症反应、上皮化困难和难以血管化等因素,治疗上存在诸多困难。近年来有关脂肪干细胞(ADSCs)促进慢性创面愈合的相关研究日益增多,多项证据表明,ADSCs可通过调控巨噬细胞功能和细胞免疫,促进血管生成及上皮化等机制促进慢性创面的愈合。本文对慢性创面的治疗难点、ADSCs治疗慢性创面的优势及作用机制等进行综述,旨在为慢性创面的干细胞治疗提供参考。

Various methods are used to treat wounds clinically,but there are still many difficulties in the treatment of chronic wounds due to excessive inflammatory response,difficulties in epithelialization,vascularization,and other factors.With the increasing research on adipose-derived stem cells(ADSCs)in recent years,many evidences show that ADSCs scan promote the healing of chronic wounds by regulating macrophages function and cellular immunity,promoting angiogenesis and epithelialization.In order to provide reference for the stem cell therapy of chronic wounds,this paper reviewed the difficulties in the treatment of chronic wounds,the advantages and the mechanism of ADSCs in promoting the healing of chronic wounds.