缺氧骨髓微环境在急性髓细胞白血病中的研究现状

Research status of hypoxic bone marrow microenvironment in acute myeloid leukemia

急性髓细胞白血病(AML)是一种高度异质性的血液肿瘤。目前, AML的主要治疗方法为化疗和造血干细胞移植(HSCT), 而残留白血病干细胞(LSC)所致的化疗耐药和复发仍是其治疗难题。近年, 缺氧骨髓微环境(BMM)被证明可促进LSC逃避化疗药物的杀伤, 并产生耐药性。因此, 针对缺氧BMM的治疗策略, 可能是未来AML极具临床应用前景的治疗方法。笔者通过对缺氧BMM与AML关系的概述、缺氧BMM在AML发病机制中的作用、抑制缺氧BMM治疗AML等方面的研究现状进行阐述, 旨在为探索AML的新靶向治疗途径提供理论依据。

Acute myeloid leukemia(AML)is a highly heterogeneous hematologic malignancy for which the main treatments are chemotherapy and hematopoietic stem cell transplantation(HSCT),but drug resistance and relapse caused by residual leukemia stem cells(LSC)remain a therapeutic challenge.In recent years,the hypoxic bone marrow microenvironment(BMM)has been shown to promote LSC to evade chemotherapeutic drug killing and acquire drug resistance.Hypoxic BMM treatment strategy for AML is one of the attractive therapeutic targets for the future.This article presents research status of relationship between hypoxic BMM and AML,role of hypoxic BMM in pathogenesis of AML,and aspects of hypoxic BMM inhibition therapy of AML,aiming to provide a theoretical basis for exploring new targeted therapeutic avenues for AML.