血清基质金属蛋白酶-12及微小RNA-22水平与胃癌患者临床病理特征的相关性分析

Analysis on correlation between serum matrix metalloproteinase-12,microRNA-22 levels and clinicopathological features of patients with gastric cancer

目的:分析血清基质金属蛋白酶-12(MMP-12)水平、微小RNA-22(miR-22)mRNA相对表达量对胃癌患者临床病理特征的影响。方法:选取2020年2月-2021年2月收治的90例胃癌患者为研究对象。观察患者的临床病理特征,并检测血清MMP-12水平、miR-22 mRNA相对表达量,分析血清MMP-12水平、miR-22 mRNA相对表达量对胃癌患者临床病理特征的影响。结果:肿瘤细胞转移及扩散患者、TNM分期Ⅲ~Ⅳ期患者的血清MMP-12水平高于肿瘤细胞未转移及扩散患者、TNM分期Ⅰ~Ⅱ期患者,均差异有统计学意义(P<0.05);miR-22 mRNA相对表达量低于肿瘤细胞未转移及扩散患者、TNM分期Ⅰ~Ⅱ期患者,均差异有统计学意义(P<0.05)。回归分析结果显示,血清MMP-12水平、miR-22 mRNA相对表达量与胃癌患者的临床病理特征有关(P<0.05)。绘制受试者工作特征曲线,结果显示胃癌患者血清MMP-12水平、miR-22 mRNA相对表达量评估肿瘤细胞转移、扩散和TNM高分期风险的曲线下面积均>0.70,评估价值较理想,且两者联合评估的价值最高。结论:血清MMP-12水平、miR-22 mRNA相对表达量与胃癌患者的临床病理特征具有一定的相关性。

Objective:To investigate the effect of serum matrix metalloproteinase-12(MMP-12)level and relative expression of microRNA(miR)-22 mRNA on clinicopathological characteristics in patients with gastric cancer.Methods:Ninety patients with gastric cancer from February 2020 to February 2021 were prospectively selected.The clinicopathological characteristics of patients was observed,the serum MMP-12 level and the relative expression of miR-22 mRNA of patients were detected,the effect of serum MMP-12 level and miR-22 mRNA relative expression on clinicopathological characteristics in patients with gastric cancer were analyzed.Results:The levels of serum MMP-12 in patients with metastasis and diffusion of tumor cells and patients with stageⅢ-Ⅳwere higher than those in patients without metastasis and diffusion of tumor cells and patients with stageⅠ-Ⅱ,the relative expression of miR-22 mRNA was lower than that in patients without metastasis and diffusion of tumor cells and patients with stageⅠ-Ⅱ,the difference was statistically significant(P<0.05);the results of regression analysis showed that the serum MMP-12 level and relative expression of miR-22 mRNA were related to the clinicopathological features of patients with gastric cancer(P<0.05);the receiver operating curve was drawn,the area under the curve of the serum MMP-12 level and the relative expression of miR-22 mRNA in gastric cancer patients for predicting the risk of tumor cell metastasis,diffusion and high TNM staging were>0.70,the predictive value was ideal,and the joint prediction value was the best.Conclusion:The serum MMP-12 level and the relative expression of miR-22 mRNA are correlated with the clinicopathological features of patients with gastric cancer.