摘要
肝细胞癌(HCC)是典型的炎症相关性癌症,肿瘤免疫微环境(TIME)在HCC发生、发展和抗肿瘤治疗反应中发挥关键作用,尤其免疫治疗效果与TIME密切相关,因此,靶向免疫微环境是治疗肝细胞癌的一项具有吸引力的策略。现阐述HCC免疫微环境的特点,基于免疫微环境的治疗方法,以及HCC对免疫疗法产生应答或抗性背后的免疫微环境信息。
The tumor immune microenvironment(TIME)plays crucial roles in the growth,progression,and therapeutic response of hepatocellular carcinoma(HCC)which is a prototypical inflammation-associated cancer.The efficacy of immunotherapy largely depends on the TIME.Targeting the immune microenvironment is an attractive strategy for the treatment of HCC.This review provides the characteristics of immune microenvironment of HCC,therapeutic approaches based on immune microenvironment,and information on the immune microenvironment underlying the response or resistance of HCC to immunotherapies.
作者
苗同国
南月敏
Miao Tongguo;Nan Yuemin(Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2022年第9期923-930,共8页
Chinese Journal of Hepatology
关键词
肝细胞癌
免疫微环境
免疫治疗
免疫细胞
免疫检查点
Hepatocellular carcinoma
Immune microenvironment
Immunotherapy
Immune cells
Immune checkpoint