肝细胞癌的免疫微环境

Hepatocellular carcinoma immune microenvironment

肝细胞癌(HCC)是典型的炎症相关性癌症,肿瘤免疫微环境(TIME)在HCC发生、发展和抗肿瘤治疗反应中发挥关键作用,尤其免疫治疗效果与TIME密切相关,因此,靶向免疫微环境是治疗肝细胞癌的一项具有吸引力的策略。现阐述HCC免疫微环境的特点,基于免疫微环境的治疗方法,以及HCC对免疫疗法产生应答或抗性背后的免疫微环境信息。

The tumor immune microenvironment(TIME)plays crucial roles in the growth,progression,and therapeutic response of hepatocellular carcinoma(HCC)which is a prototypical inflammation-associated cancer.The efficacy of immunotherapy largely depends on the TIME.Targeting the immune microenvironment is an attractive strategy for the treatment of HCC.This review provides the characteristics of immune microenvironment of HCC,therapeutic approaches based on immune microenvironment,and information on the immune microenvironment underlying the response or resistance of HCC to immunotherapies.