丙戊酸钠治疗心境障碍-躁狂症患者的症状改善效果

Improvement Effect of Symptoms of Mood Disorder Mania Treated with Valproate

目的对心境障碍-躁狂症疾病实施丙戊酸钠药物干预后,探析其临床症状改善效果。方法本研究为回顾性分析,选取2018年5月至2019年10月至本院治疗的躁狂症且自愿接受药物治疗患者90例,按照随机打乱后的名单单双号排序,将其平均分为两组,即为常规组与试验组,每组45例。常规组患者给予碳酸锂药物治疗,试验组患者给予丙戊酸钠治疗,比较两组并发症发生情况、治疗前后躁狂症情况[贝克-拉范森躁狂量表(BRMS)]、治疗效果以及治疗依从性。结果试验组治疗依从性(93.33%)高于常规组(77.78%),组间数值差异有统计学意义(χ^(2)=4.405,P<0.05)。试验组并发症总发生率(11.11%)明显低于常规组(42.22%),组间差异有统计学意义(χ^(2)=11.136,P<0.05)。治疗前,试验组与常规组躁狂症控制情况相比较差异无统计学意义,P>0.05;治疗后,试验组破坏行为与敌意评分为(3.00±0.50)分、睡眠障碍评分为(3.10±0.20)分、情绪不佳评分为(2.10±0.60)分、言语不善评分为(4.70±1.10)分、意念飘忽评分为(4.70±1.10)分、夸大评价评分为(3.20±0.50)分,均较常规组的躁狂症表现明显较低,组间差异有统计学意义(P<0.05);常规组总体治疗效果(55.56%)相比试验组(66.67%)较差,用药效果不佳,组间差异有统计学意义(χ^(2)=12.461,P<0.05)。结论面对心境障碍-躁狂症的临床治疗选择丙戊酸钠的治疗效果显著提升,躁狂症不良情绪表现有所控制,治疗安全性较高,且患者治疗依从性较高。

Objective To explore the effect of improving the clinical symptoms of mood disorder mania after the treatment of valproate.Methods A total of 90 patients with mania from May 2018 to October 2019 in our hospital were selected by retrospective analysis,and randomly divided into two groups,i.e.conventional group and experimental group,45 patients in each group.The patients in the routine group were treated with lithium carbonate,and the patients in the experimental group were treated with sodium valproate.The incidence of adverse complications,mania before and after treatment(BRMS),treatment effect and treatment compliance were compared between the two groups.Results The treatment compliance of the experimental group(93.33%)was higher than that of the conventional group(77.78%),and the numerical difference between the groups was larger(χ^(2)=4.405,P<0.05).The total incidence of adverse complications in the experimental group(11.11%)was significantly lower than the conventional group(42.22%),the difference between the groups was large(χ^(2)=11.136,P<0.05).There was no significant difference in the control of mania between the experimental group and the conventional group before treatment,P>0.05.After treatment,the scores of disruptive behavior and hostility in the experimental group were(3.00±0.50),the score of sleep disturbance was(3.10±0.20),the score of bad mood was(2.10±0.60),and the score of bad speech was(4.70±1.10)score,the score of erratic thinking was(4.70±1.10),and the score of exaggerated evaluation was(3.20±0.50),which were significantly lower than those of the conventional group,and the difference between the groups was statistically significant(P<0.05).The general treatment effect(55.56%)of the conventional group is compared with the experimental group(66.67%)is poor,the medication effect is not good,the number difference between groups(χ^(2)=12.461,P<0.05).Conclusion In the face of mood disorders-mania,sodium valproate is selected for clinical treatment.The clinical treatment effect is significantly improved,the adverse emotional performance of mania is controlled,the treatment safety is high,and the patient's treatment compliance is high.