运动减轻孤独症神经炎症的可视化分析

Mechanism of exercise reducing neuroinflammation in autism spectrum disorder:a visualized analysis

目的探索近10年来孤独症谱系障碍(ASD)-小胶质细胞研究领域的热点及未来发展趋势,对ASD的神经炎症以及运动减轻ASD症状的免疫调控机制及可能的通路进行综述。方法从Web of Science核心数据库中检索2012年1月至2021年12月ASD-小胶质细胞相关研究。采用CiteSpace 5.8.R3软件对纳入文献的年度发文量、高频关键词及关键词聚类等进行可视化分析。结果与结论共纳入783篇文献,发文量总体呈上升趋势。神经炎症是ASD发病机制相关研究的热点,其中小胶质细胞的异常激活、炎性细胞因子水平的改变是ASD发生、发展的重要因素。运动是改善ASD的重要干预方法,可能通过减轻神经炎症或调控小胶质细胞介导的炎症通路实现。

Objective To explore the research hotspots and development trends in the field of autism spectrum disorder(ASD)in the past ten years,the literatures of microglia-related neuroinflammation of ASD and the immune regulation and pos‐sible pathways of exercise ameliorating ASD symptoms were reviewed.Methods Articles about microglia-related research in ASD during January,2012 to December,2021 were searched in the core collection database of Web of Science.The CiteSpace 5.8.R3 software was used to summarize the main find‐ings,visualize and analyze the annual publication volume,high-frequency keywords and keyword clustering.Results and Conclusion A total of 783 papers were returned.The numbers of papers published increased with time.The neuroinflammation was a research hotspot in the pathogenesis of ASD,among which abnormal activation of mi‐croglia and the levels of inflammatory cytokines were important factors in the occurrence and development of ASD.Exercise was an important intervention to improve symptoms of ASD,which may associate with reducing neuroinflammation or regulating microglia-mediated inflammatory pathways.