基于结构协变网络探索卒中后失语结构损伤特征

Characteristics of post-stroke aphasia structural damage based on structural covariance network

目的基于高阶结构协变网络探讨卒中后失语(PSA)患者灰质结构异常改变。方法2019年6月至2022年3月,招募北京中医药大学东直门医院和北京博爱医院的PSA患者15例(患者组),同时招募健康受试者15例(对照组),采集大脑结构磁共振成像数据,由灰质体积相关性构建大脑协变网络,并使用图论分析方法评估结构协变网络的全局及节点网络水平拓扑属性,比较患者组和对照组灰质协变网络属性的组间差异。结果全局网络水平,两组拓扑属性比较无显著性差异(P>0.05)。在节点水平,与对照组相比,患者组在右侧眶部额中回、右侧后扣带回、右侧杏仁核、左侧枕中回介数降低,右侧岛盖部额下回、右侧枕下回介数升高(P<0.05);左侧眶内额上回、左侧前扣带和旁扣带脑回、左侧海马、左侧杏仁核节点度降低,右侧岛盖部额下回、左侧补充运动区、右侧枕上回、右侧枕下回、右侧豆状苍白球节点度升高(P<0.05);左侧前扣带和旁扣带回、左侧海马、左侧杏仁核、左侧颞极:颞上回节点效率下降,右侧岛盖部额下回、左侧补充运动区、右侧枕下回节点效率升高(P<0.05)。结论PSA患者左侧半球部分脑区节点网络属性异常降低可能是其特征性结构协变模式,并且右侧半球可能出现部分脑区结构网络的代偿。

Objective To investigate the abnormal changes of gray matter structure covariant network in post-stroke aphasia(PSA)patients.Methods From June,2019 to March,2022,15 PSA patients(patient group)from Dongzhimen Hospital,Beijing Univer‐sity of Chinese Medicine and Beijing Bo'ai Hospital were recruited,as well as 15 healthy subjects(control group).Their brain structure magnetic resonance imaging data were collected.The brain covariant network was constructed based on gray matter volume correlation,and graph theory analysis method was used to evaluate the global and node network level topology properties of structural covariant network.The differences of gray matter covariant network properties between patients and controls were compared.Results There was no significant difference in the global network level topology properties between two groups(P>0.05).At the nodal level,compared with the control group,the betweenness decreased in the right middle frontal gyrus,right posterior cingulate gyrus,right amygdala,left middle occipital gyrus,and increased in the right inferi‐or frontal gyrus and the right suboccipital gyrus of the insula operculum(P<0.05);the node degree decreased in the left superior frontal gyrus,left anterior cingulate and paracingulate gyrus,left hippocampus and left amygda‐la,while it increased in the right inferior frontal gyrus,left supplementary motor area,right superior occipital gy‐rus,right inferior occipital gyrus,and right lentiform pallidus(P<0.05);the node efficiency decreased in the left anterior cingulate and paracingulate gyrus,left hippocampus,left amygdala,left temporal pole:superior temporal gyrus,and increased in the inferior frontal gyrus of right insula,left supplementary motor area and right suboccip‐ital gyrus(P<0.05).Conclusion The abnormal reduction of node network properties in some brain regions in the left hemisphere of PSA pa‐tients may be a characteristic structural covariation pattern,and there may be some compensation in the right hemisphere of the structural network in some brain regions.