黄芪建中汤合理中汤治疗脾胃虚寒型慢性胃炎的疗效及对患者血清炎症因子和胃肠激素的影响

Curative effect of Huangqi Jianzhong Decoction combined with Lizhong Decoction for chronic gastritis of spleen-stomach deficiency cold and how to impact on serum inflammatory factor and gastrointestinal hormone

目的 观察黄芪建中汤合理中汤治疗脾胃虚寒型慢性胃炎(CG)的疗效及对患者血清炎症因子和胃肠激素的影响。方法 将96例脾胃虚寒型CG患者按照随机数字表法分为2组,对照组48例予西医常规治疗,治疗组48例在对照组治疗基础上加用黄芪建中汤合理中汤治疗。2组均治疗2个月。比较2组疗效;比较2组治疗前后中医证候评分变化;比较2组治疗前后血清炎症因子含量变化;比较2组治疗前后血清胃肠激素指标变化。结果 治疗组总有效率95.74%(45/47),对照组总有效率81.82%(36/44),治疗组疗效优于对照组(P<0.05)。2组治疗后中医证候各项评分及总评分均较本组治疗前降低(P<0.05),治疗后治疗组胃痛隐隐,绵绵不休、喜温喜按、劳累或受凉后发作或加重、精神疲倦评分及总评分均低于对照组(P<0.05)。2组治疗后血清白细胞介素1β(IL-1β)、IL-6、肿瘤坏死因子α(TNF-α)含量均较本组治疗前降低(P<0.05),治疗后治疗组血清IL-1β、IL-6、TNF-α含量均低于对照组(P<0.05)。2组治疗后血清胃动素(MTL)、胃泌素(GAS)均较本组治疗前升高(P<0.05),生长抑素(SS)较本组治疗前降低(P<0.05);治疗后治疗组血清MTL、GAS均高于对照组(P<0.05),SS低于对照组(P<0.05)。结论 黄芪建中汤合理中汤治疗脾胃虚寒型CG,能提高患者临床疗效,可能与抑制炎症浸润程度、调节胃肠激素有关。

Objective To observe the curative effect of Huangqi Jianzhong Decoction combined with Lizhong Decoction for chronic gastritis(CG)of spleen-stomach deficiency cold and how to impact on inflammatory factor and gastrointestinal hormone.Methods Totally 96 patients with CG(spleen-stomach deficiency cold)were randomly assigned into the treatment group(n=48)and the control group(n=48);in addition to the routine Western medicine,and the treatment group additionally received Huangqi Jianzhong Decoction combined with Lizhong Decoction.Treated for 2 month,aiming to compare traditional Chinese medicine(TCM)syndrome score,inflammatory factor,serum gastrointestinal hormone index;the curative effect was assessed.Results The overall effective rate was higher in the treatment group(95.74%[45/47])compared with the control group(81.82%[36/44]),(P<0.05).After treatment,TCM symptom scores in groups were decreased(P<0.05),TCM symptom(recessive stomach pain,uninterrupted,like to warm and press,outbreak or aggravation after fatigue or cold,mental fatigue)scores were decreased in the treatment group compared with the control group(P<0.05);interleukin-1β(IL-1β),IL-6,tumor necrosis factor-a(TNF-α)in groups were decreased(P<0.05),the treatment group was more common(P<0.05);serum motilin(MTL)and gastrin(GAS)in groups were increased(P<0.05),while somatostatin(SS)in groups was decreased(P<0.05);higher MTL and GAS,and lower SS were detected in the treatment group than those in the control group(all P<0.05).Conclusion For CG patients(spleen-stomach deficiency cold),Huangqi Jianzhong Decoction combined with Lizhong Decoction can improve the clinical efficacy by inhibiting inflammatory infiltration and regulating gastrointestinal hormone.