“补肾强志、填精益脑”方辅助治疗精神分裂症阴性症状患者的临床回顾性分析

A Retrospective Study of Bushenqiangzhi Tianjingyinao Formulain Adjuvant Treatment of Negative Symptoms of Schizophrenia

目的回顾性分析“补肾强志、填精益脑”方(BSQZF)辅助治疗精神分裂症阴性症状患者的临床疗效。方法选取2007年6月—2019年11月期间在北京市大兴区心康医院住院治疗的62例精神分裂症患者,根据随机数字表法分为对照组和治疗组,每组各31例。对照组使用常规抗精神病药物进行治疗,治疗组在对照组基础上使用BSQZF加减辅助治疗。观察比较两组患者治疗前后阳性与阴性症状量表(PANSS)量表、生活质量、临床疗效及不良反应情况。结果治疗后治疗组患者阴性症状评分较治疗前明显下降,差异有统计学意义(P<0.05);且治疗组患者阴性症状评分较对照组明显降低,差异有统计学意义(P<0.05),阳性症状、一般精神病理评分则无明显变化(P>0.05)。治疗后治疗组患者心理、社会评分均较对照组明显升高,差异有统计学意义(P<0.05);且治疗组患者心理、社会评分均较治疗前明显升高,差异有统计学意义(P<0.05),生理、环境评分则无明显变化(P>0.05)。治疗后治疗组总有效率35.48%(11/31)明显高于对照组12.90%(4/31),差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论使用BSQZF为基础方加减辅助治疗有助于改善精神分裂症患者的阴性症状,提升生活质量,且安全性良好。

To analyze the effect of Bushenqiangzhi Tianjingyinao Formula(BSQZF)on negative symptoms of schizophrenia.Methods The data of 62 patients with schizophrenia who were hospitalized in Beijing Daxing Xinkang Hospital from June 2007 to November 2019 were included for retrospective analysis.They were grouped with the random number table method:31 cases in the control group who were treated with conventional antipsychotics,and 31 cases in the experimental group who were treated with conventional antipsychotics and modified BSQZF.The Positive and Negative Syndrome Scale(PANSS)score,quality of life,clinical efficacy,and occurrence of adverse reactions before and after treatment were compared between the two groups.Results The score of the negative symptoms was lower than that before treatment in both groups(P<0.05)and lower in the experimental group than in the control group(P<0.05).The scores of positive symptoms and general psychopathology showed no significant difference between the control group and the experimental group(P>0.05).After treatment,scores of psychological relationship and social relationship were higher than those before treatment in the experimental group(P<0.05)and higher in the experimental group than those in the control group(P<0.05),but the scores of physical health and environment showed no significant variation(P>0.05).The total effective rate was 35.48%(11/31)in the experimental group,as compared with the 12.90%(4/31)in the control group(P<0.05).The occurrence of adverse reactions demonstrated no significant difference between the two groups(P>0.05).Conclusion Adjuvant treatment with BSQZF helps improve negative symptoms and quality of life with a good safety profile.