妊娠期SCH患者血脂、RE及lipocalin-2水平变化及临床意义分析

Analysis of changes and clinical significance of blood lipid,resistin and lipocalin-2 levels in SCH patients during pregnancy

目的 分析妊娠期亚临床甲状腺功能减退症(SCH)患者各项血脂指标以及抵抗素(RE)、中性粒细胞明胶酶相关脂质运载蛋白-2(lipocalin-2)的变化及临床意义,为临床治疗提供科学依据。方法 选取2020年3月—2021年3月我院收治的妊娠期SCH患者127例(研究组)及同时期于我院进行孕检的甲状腺功能正常的孕妇420例作为研究对象(对照组),采用全自动生化分析仪检测2组孕妇各血脂指标[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、同型半胱氨酸(Hcy)]水平,应用酶联免疫吸附实验检测RE、lipocalin-2水平,并对数据进行统计分析。结果 研究组孕妇TSH、TC、TG、Hcy、LDL-C水平均高于对照组(均P<0.05),HDL-C水平与对照组的差异无统计学意义(P>0.05)。研究组孕妇RE水平低于对照组,而lipocalin-2水平高于对照组,且差异均有统计学意义(P<0.05)。相关分析结果显示:lipocalin-2与TG、TC、LDL-C水平呈正相关(均P<0.05),RE与TG、TC、LDL-C水平呈负相关(均P<0.05)。结论 RE、lipocalin-2水平可在一定程度上反映SCH孕妇的血脂水平。对于妊娠期合并SCH患者,应当及时检测血脂、RE和lipocalin-2水平,进行早期筛查,并给予有效方案治疗。临床应提高对妊娠期SCH患者的重视程度,以减少不良妊娠结局的发生。

Objective To analyze the changes and clinical significance of blood lipid parameters, resistin(RE), and neutrophil gelatinase-associated lipocalin-2(lipocalin-2) in patients with subclinical hypothyroidism(SCH) during pregnancy to provide scientific evidence for clinical treatment. Methods A total of 127 pregnant women with SCH during pregnancy(study group) and 420 euthyroid pregnant women(control group) who underwent pregnancy tests in our hospital from March 2020 to March 2021 were selected as the study subjects and controls, respectively. The levels of blood lipid parameters [high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), total cholesterol(TC), triacylglycerol(TG), and homocysteine(Hcy)] were measured by the automatic biochemical analyzer. The levels of RE and lipocalin-2 were measured by enzyme-linked immunosorbent assay. The data were statistically analyzed. Results The levels of TSH, TC, TG, Hcy, and LDL-C in the study group were significantly higher than those in the control group(all P<0.05), and there was no significant difference in HDL-C levels between the study group and the control group(P>0.05). In the study group, RE levels were lower while lipocalin-2 levels were higher than those in the control group, and the differences were statistically significant(P<0.05). Correlation analysis showed that lipocalin-2 was positively correlated with TG,LDL-C and TC levels(all P<0.05),RE was negatively correlated with TG,TC and LDL-C levels(all P<0.05). Conclusion The levels of RE and lipocalin-2 can reflect the blood lipid level of pregnant women with SCH to some extent. For pregnant women with SCH, blood lipid, RE and lipocalin-2 levels should be promptly measured for early screening and effective regimen treatment should be given. More attention should be paid to SCH patients during pregnancy to reduce the occurrence of adverse pregnancy outcomes.