摘要
HSP90作为热休克蛋白家族中最重要的成员,HSP90不仅可以作为癌基因的分子伴侣发挥其重要作用,而且在肿瘤的生长,进展阶段中扮演着重要角色,HSP90在多种癌蛋白的信号通路及信号转导中起着至关重要的作用。HSP90的高表达与泌尿系统肿瘤的发生,发展也密切相关。在肾癌、膀胱癌和前列腺癌中,HSP90均高表达,并且促进这三大肿瘤的发展。抑制HSP90的水平在泌尿系统肿瘤的治疗中也具有重要的研究意义。现对HSP90的生理学特征及其在泌尿系统肿瘤中的作用机制作一综述。
HSP90 is the most important member of the heat shock protein family.As a molecular chaperone,HSP90 not only participates in the correct folding process after protein translation,but also plays an important role in the growth and progression of tumors.HSP90 plays a critical role in several oncogene pathways and signal transduction proteins.HSP90 is also closely related to the occurrence and development of urinary system tumors.HSP90 is highly expressed in renal cancer,bladder cancer and prostate cancer and promotes the development of these three major tumors.Inhibition of HSP90 levels also has important research significances in the treatment of urinary system tumors.This article reviews the physiological characteristics of HSP90 and its mechanism in urinary system tumors.
作者
王雅轩
王小林
WANG Yaxuan;WANG Xiaolin(Medical School of Nantong University,Jiangsu Nantong 226019,China;Affiliated Tumor Hospital of Nantong University&Nantong Tumor Hospital,Jiangsu Nantong 226361,China)
出处
《现代肿瘤医学》
CAS
北大核心
2022年第22期4200-4203,共4页
Journal of Modern Oncology
基金
江苏省卫生健康委科研项目(编号:M2021005)
江苏省南通市科技计划项目(编号MS22019010)
江苏省南通市卫生健康委员会科研课题(编号:QA2020022,QA2020023)。
关键词
HSP90
肾癌
膀胱癌
前列腺癌
HSP90
renal cancer
bladder cancer
prostate cancer
