临床质谱技术发展态势分析及建议

The Development Trend and Suggestions of Clinical Mass Spectrometry

质谱技术通过测量离子质荷比以准确鉴定未知分析物,定量已知化合物以及确定分子的结构和化学性质。近年来,其在生命科学基础研究和临床检测分析中的应用越来越广泛,为理解生命组成和生命现象本质,实现疾病快速准确诊断提供了重要支撑。本文分析了国际和中国临床质谱技术发展现状和问题,并提出了相关政策建议。分析结果显示,离子源、质量分析器的技术进步,以及离子淌度谱技术的创新性引入提高了质谱技术的灵敏度、分辨率,拓宽了可检测分子范围,并使得质谱技术的定性和定量能力获得显著的提升,这些发展助力质谱技术临床应用进入快速发展阶段。中国临床质谱技术研发和应用起步较晚,未来需进一步加强源头技术自主创新,推进临床应用下沉,并逐步完善相关监管规范。

Through measuring ion mass-to-charge ratio,mass spectrometry technology accurately identifies unknown analytes,quantifies known compounds,and determines the structure and chemical properties of molecules.In recent years,its application in life science basic research and clinical detection analysis has become more and more extensive,providing important support for understanding the composition of life and the essence of life phenomena,and realizing rapid and accurate diagnosis of diseases.This article analyzes the development status and problems of international and Chinese clinical mass spectrometry technology,and puts forward relevant policy recommendations.It shows that technological advances in ion sources and mass analyzers,as well as the introduction of innovative ion mobility spectroscopy technology,have improved the sensitivity and resolution of mass spectrometry,broadened the range of detectable molecules,and significantly improved the qualitative and quantitative capabilities of mass spectrometry,which make the clinical application of mass spectrometry technology enter a stage of rapid development.Chinese clinical mass spectrometry technology research and application started relatively late,and it is necessary to further strengthen the independent innovation of source technology,promote the sinking of clinical applications,and gradually improve related regulatory standards in the future.