益生菌联合四联疗法对Hp阳性消化性溃疡患者炎症相关因子、免疫功能、胃功能的影响

Effects of probiotics combined with quadruple therapy on inflammatory related factors,immunologic function and gastric function in patients with Hp positive peptic ulcer

目的探讨益生菌联合四联疗法对幽门螺杆菌(Hp)阳性消化性溃疡患者炎症相关因子、免疫功能、胃功能的影响。方法选择我院2019年5月至2021年5月收治的100例Hp阳性消化性溃疡患者为研究对象,将其随机分为对照组和试验组,各50例。对照组采取四联疗法,试验组采取益生菌联合四联疗法。比较两组的临床疗效、炎症相关因子水平、免疫功能指标、胃功能指标、症状缓解时间及不良反应发生情况。结果试验组的治疗总有效率为94.00%,显著高于对照组的72.00%,差异具有统计学意义(P<0.05)。治疗后,两组的氧化氮(NO)、骨桥蛋白(OPN)、白细胞介素-33(IL-33)水平较治疗前降低,表皮生长因子(EGF)、白细胞介素-35(IL-35)水平较治疗前升高,且试验组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的白细胞分化抗原8阳性(CD8^(+))较治疗前降低,白细胞分化抗原4阳性(CD4^(+))、CD4^(+)/CD8^(+)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)水平较治疗前升高,且试验组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的胃泌素、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ水平均低于治疗前,且试验组低于对照组(P<0.05)。试验组的反酸及嗳气缓解时间均短于对照组,差异具有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论益生菌联合四联疗法治疗Hp阳性消化性溃疡的效果显著,有助于降低炎症相关因子水平,改善机体免疫功能和胃功能,快速缓解临床症状,保障用药安全。

Objective To investigate the effects of probiotics combined with quadruple therapy on inflammatory related factors,immunologic function and gastric function in patients with Helicobacter pylori(Hp)positive peptic ulcer.Methods One hundred patients with Hp positive peptic ulcer admitted in our hospital from May 2019 to May 2021 were selected as the research objects and randomly divided into control group and experimental group,with 50 cases in each group.The control group was treated with quadruple therapy,and the experimental group was treated with probiotics combined with quadruple therapy.The clinical efficacy,levels of inflammatory related factors,immunologic function indicators,gastric function indicators,symptom relief time and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the experimental group was 94.00%,which was significantly higher than 72.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of nitrogen oxide(NO),osteopontin(OPN)and interleukin-33(IL-33)in the two groups were lower than those before treatment,the levels of epidermal growth factor(EGF)and interleukin-35(IL-35)were higher than those before treatment,those of the experimental group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,cluster of differentiation 8 positive(CD8^(+))was lower than that before treatment,cluster of differentiation 4 positive(CD4^(+)),CD4^(+)/CD8^(+),immune protein G(IgG)and immune protein A(IgA)levels were higher than those before treatment,those of the experimental group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of gastrin,pepsinogenⅠand pepsinogenⅡin both groups were lower than those before treatment,those of the experimental group were lower than the control group,and the differences were statistically significant(P<0.05).The remission time of sour regurgitation and belching in the experimental group were shorter than those in the control group,and the difference was statistically significant(P<0.05);there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Probiotics combined with quadruple therapy in the treatment of Hp positive peptic ulcer has a significant effect,which can reduce the levels of inflammatory related factors,improve the immunologic function and gastric function of the body,quickly alleviate clinical symptoms,and ensure drug safety.