腹腔镜下子宫动脉阻断术加子宫肌瘤剔除术对子宫肌瘤患者卵巢功能及氧化损伤指标的影响

Effects of laparoscopic uterine artery occlusion and myomectomy on ovarian function and oxidative damage indexes in patients with uterine fibroids

目的探讨腹腔镜下子宫动脉阻断术加子宫肌瘤剔除术治疗子宫肌瘤的效果。方法选取2019年1月至2021年1月我院收治的120例子宫肌瘤患者作为研究对象,按照随机数字表法将其分为对照组与观察组,各60例。对照组实施腹腔镜下子宫肌瘤剔除术,观察组实施腹腔镜下子宫动脉阻断术加子宫肌瘤剔除术。比较两组的治疗效果。结果两组的手术时间、术后肠鸣音恢复时间、肛门排气时间、进食时间、住院时间无明显差异(P>0.05);观察组的术中出血量少于对照组(P<0.05)。术前、术后3个月,两组的黄体生成素(LH)、雌二醇(E2)、促卵泡生成素(FSH)水平及窦卵泡计数(AFC)无显著差异(P>0.05)。术后3 d,两组的血清肌红蛋白(MYO)、缺血修饰清蛋白(IMA)水平均高于术前,八廓环磷酰胺水平均低于术前(P<0.05);但两组组间无显著差异(P>0.05)。观察组的术后并发症总发生率与复发率显著低于对照组(P<0.05)。观察组的术后成功分娩率显著高于对照组(P<0.05)。结论腹腔镜下子宫动脉阻断术加子宫肌瘤剔除术治疗子宫肌瘤的效果显著,能够减少术中出血量,降低术后并发症总发生率与复发率,提高成功分娩率。

Objective To investigate the effect of laparoscopic uterine artery occlusion and myomectomy in the treatment of uterine fibroids.Methods A total of 120 patients with uterine fibroids admitted in our hospital from January 2019 to January 2021 were selected as the research objects,and the patients were divided into control group and observation group according to the random number table method,with 60 cases in each group.The control group underwent laparoscopic myomectomy,and the observation group underwent laparoscopic uterine artery occlusion and myomectomy.The therapeutic effects of the two groups were compared.Results There were no significant differences in operation time,postoperative bowel sound recovery time,anal exhaust time,eating time and hospitalization time between the two groups(P>0.05);the amount of intraoperative bleeding in the observation group was less than that in the control group(P<0.05).There were no significant differences in the levels of luteinizing hormone(LH),estradiol(E2),follicle-stimulating hormone(FSH)and antral follicle count(AFC)between the two groups before operation and at 3 months after operation(P>0.05).Three days after operation,the levels of serum myoglobin(MYO)and ischemia modified albumin(IMA)in the two groups were higher than those before operation,and the levels of cyclophosphamide was lower than that before operation(P<0.05);but there were no significant differences between the two groups(P>0.05).The total incidence of postoperative complications and recurrence rate in the observation group were significantly lower than those in the control group(P<0.05).The postoperative successful delivery rate in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Laparoscopic uterine artery occlusion and myomectomy in the treatment of uterine fibroids has a significant effect,which can reduce the amount of intraoperative blood loss,reduce the total incidence of postoperative complications and recurrence rate and improve the successful delivery rate.