复方嗜酸乳杆菌片与消旋卡多曲颗粒联合蒙脱石散治疗小儿腹泻的效果比较

Comparison of the effect of compound Eosinophil-Lactobacillus tablets and racecadotril granules combined with montmorillonite powder in the treatment of infantile diarrhea

目的比较复方嗜酸乳杆菌片与消旋卡多曲颗粒联合蒙脱石散治疗小儿腹泻的效果。方法选取本院2018年12月至2021年6月收治的110例腹泻患儿作为研究对象,按照随机数字表法将其分为嗜酸乳杆菌组(55例,复方嗜酸乳杆菌片+蒙脱石散)和消旋卡多曲组(55例,消旋卡多曲颗粒+蒙脱石散)。比较两组患儿的治疗效果、临床症状改善时间、T淋巴细胞指标、炎症因子水平及不良反应发生情况。结果嗜酸乳杆菌组的治疗总有效率为92.73%,明显高于消旋卡多曲组的76.36%,差异具有统计学意义(P<0.05)。嗜酸乳杆菌组的腹痛缓解时间、大便恢复正常时间、脱水纠正时间均明显短于消旋卡多曲组,差异具有统计学意义(P<0.05)。治疗后,嗜酸乳杆菌组的白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))、白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))明显高于消旋卡多曲组,白细胞分化抗原8阳性(CD8^(+))明显低于消旋卡多曲组,差异具有统计学意义(P<0.05)。治疗后,嗜酸乳杆菌组的白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平明显低于消旋卡多曲组,白细胞介素-10(IL-10)水平明显高于消旋卡多曲组,差异具有统计学意义(P<0.05)。嗜酸乳杆菌组的不良反应总发生率明显低于消旋卡多曲组,差异具有统计学意义(P<0.05)。结论复方嗜酸乳杆菌片联合蒙脱石散治疗小儿腹泻的效果优于消旋卡多曲颗粒联合蒙脱石散,可快速缓解临床症状,提高患儿的免疫力,减轻炎症反应,且安全性较高,值得临床推广应用。

Objective To compare the effect of compound Eosinophil-Lactobacillus tablets and racecadotril granules combined with montmorillonite powder in the treatment of infantile diarrhea.Methods A total of 110 children with diarrhea admitted in our hospital from December 2018 to June 2021 were selected as the research objects,and the children were divided into Eosinophil-Lactobacillus group(55 cases,compound Eosinophil-Lactobacillus tablets+montmorillonite powder)and racecadotril group(55 cases,racecadotril granules+montmorillonite powder)according to random number table method.The therapeutic effect,improvement time of clinical symptoms,T lymphocyte indexes,inflammatory factors levels and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the Eosinophil-Lactobacillus group was 92.73%,which was significantly higher than 76.36%in the racecadotril group,and the difference was statistically significant(P<0.05).The time of abdominal pain relief,stool return to normal and dehydration correction in the Eosinophil-Lactobacillus group were significantly shorter than those in the racecadotril group,and the differences were statistically significant(P<0.05).After treatment,the cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 4 positive(CD4^(+))and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+))in the Eosinophil-Lactobacillus group were significantly higher than those in the racecadotril group,while the cluster of differentiation 8 positive(CD8^(+))was significantly lower than that in the racecadotril group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the EosinophilLactobacillus group were significantly lower than those in the racecadotril group,and the level of interferon-10(IL-10)was significantly higher than that in the racecadotril group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the Eosinophil-Lactobacillus group was significantly lower than that in the racecadotril group,and the difference was statistically significant(P<0.05).Conclusion Compound Eosinophil-Lactobacillus tablets combined with montmorillonite powder is more effective than racecadotril granules combined with montmorillonite powder in the treatment of infantile diarrhea,it can quickly relieve clinical symptoms,improve the immunity of children,reduce inflammatory reaction,and has high safety,which is worthy of clinical promotion and application.