间歇性禁食对2型糖尿病肥胖患者干预效果的Meta分析

Effectiveness of intermittent fasting on obese patients with type 2 diabetes mellitus:a Meta-analysis

目的系统评价间歇性禁食对2型糖尿病肥胖患者的干预效果。方法检索中英文数据库有关间歇性禁食对2型糖尿病患者干预效果的随机对照试验,检索时间为建库至2021年12月,采用RevMan 5.3软件进行Meta分析。结果最终纳入8篇文献,共549例患者(BMI≥28)。Meta分析显示,与对照组相比,间歇性禁食可降低患者糖化血红蛋白水平、体质量、腹围,提升高密度脂蛋白胆固醇(均P<0.05),但在降低总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平方面与对照组相比差异无统计学意义(均P>0.05)。间歇性禁食组不良事件发生情况与对照组相比,差异无统计学意义(P>0.05)。结论间歇性禁食可以帮助2型糖尿病肥胖患者有效管理血糖,减轻体质量、减少腹围以及提升高密度脂蛋白胆固醇水平,且安全可行。但在改善其他血脂水平方面期待更多高质量研究证实。

Objective To evaluate the effect of intermittent fasting on obese patients with type 2 diabetes mellitus(T2DM).Methods Computer searches of Chinese and English databases were conducted from database inception to December 2021,to retrieve RCT studies on the effect of intermittent fasting on T2DM patients.RevMan 5.3 software was used for data processing.Results A total of 8 articles were included,covering 549 obese T2DM patients(all with BMI≥28).Meta-analysis showed that compared with the control group,intermittent fasting group could reduce hemoglobin A1c levels,body weight,and abdominal circumference,and elevate high density lipoprotein cholesterol levels(all P<0.05);however,there were no statistical difference in the reduction of total cholesterol,triglycerides and low density lipoprotein cholesterol levels between the 2 groups(all P>0.05).Also,there were no statistical difference in the incidence rates of adverse events between the 2 groups(P>0.05).Conclusion Intermittent fasting,being safe and feasible,can help obese T2DM patients effectively manage blood glucose,reduce body weight and abdominal circumference,and raise high density lipoprotein cholesterol levels.More high-quality studies are expected to confirm the effect of intermittent fasting on other lipid indicators.