基于MUC1为靶点的乳腺癌治疗研究进展

Reaearch progress on the treatment of breast cancer based on MUC1 gene

黏蛋白1(mucin 1,MUC1)是黏蛋白家族中最容易被识别的跨膜蛋白,在乳腺癌细胞中过度表达且糖基化水平明显降低,并在乳腺癌发生发展中起到至关重要的作用。作为乳腺癌的治疗靶点,MUC1多年来受到广泛的研究,并已经取得了显著成效。目前,以MUC1为靶点的乳腺癌的治疗研究主要包括基于配体靶向治疗、免疫疗法及一体化诊疗。本文对近年来基于MUC1基因为靶点的乳腺癌治疗研究进展情况进行综述。

Mucin 1(MUC1),the most easily recognized transmembrane protein in the mucin family,is overexpressed in breast cancer cells with significantly reduced glycosylation level,which plays a crucial role in the occurrence and development of breast cancer.As a therapeutic target for breast cancer,MUC1 has been widely studied for years and remarkable results have been achieved.Currently,the research on the treatment of breast cancer targeting MUC1 mainly includes ligand-based targeted therapy,immunotherapy and integration diagnosis and treatment.In this review,we summarize the recent research on the treatment of breast cancer based on MUC1 gene.