基于数据挖掘分析方朝晖教授治疗肝郁脾虚型甲状腺功能亢进症的用药规律

Study on the medication experience of professor Fang Zhaohui in the treatment of hyperthyroidism based on data mining analysis

目的:总结方朝晖教授应用中药治疗肝郁脾虚型甲状腺功能亢进症的临床用药特点及规律。方法:整理方朝晖教授采用中药治疗的147例肝郁脾虚型甲状腺功能亢进症患者的处方。将处方信息录入临床科研一体化系统,通过频数分析、关联规则、复杂网络等方法观察中药的频次、关联组合、核心药物等。结果:纳入处方330张,含中药177味;炙甘草、夏枯草、茯神、生地黄、茯苓、柏子仁使用频率超过50%;复杂网络图显示炙甘草、夏枯草、茯神、生地黄、茯苓、远志、五味子为核心药物;关联规则中设置信度>60%,支持度>20%的药对(2味药物)有7个,如炙甘草—牡丹皮、茯神—茯苓、夏枯草—生地黄等;三药关联中置信度>70%,支持度>10%的药对(3味药物)有11个,如茯神—远志、茯苓,夏枯草—五味子、生地黄等。结论:方朝晖教授治疗肝郁脾虚型甲状腺功能亢进症多采用药性平和的疏肝健脾、清热宁神中药。

Objective:To summarize the clinical medication characteristics and rules of Professor Fang Zhaohui in applying Chinese herbal medicine to treat hyperthyroidism due to liver qi depression and spleen deficiency.Methods:The prescriptions of 147 cases of hyperthyroidism patients with liver qi depression and spleen deficiency syndrome treated by Professor Fang Zhaohui were sorted out.The prescription information was entered into the integrated clinical research system,and the frequency,association combinations,and core drugs of Chinese medicine were observed by frequency analysis,association rules,and complex networks.Results:In this study,330 prescriptions containing 177 Chinese herbs were included;the frequencies of Radix Glycyrrhizae,Spica Prunellae,Poria(Indian Bread with Pine),Rhizoma Rehmanniae glutinosae,Poria(Indian Bread),and Semen Biotae exceeded 50%;the complex network diagram showed that Radix Glycyrrhizae,Spica Prunellae,Poria(Indian Bread with Pine),Rhizoma Rehmanniae glutinosae,Poria(Indian Bread),Polygalae,and Fructus Schisandrae Chinensis were the core drugs;there were 7 couplet medicines(2 medicines)in association rules with reliability>60%and support>20%,such as Radix Glycyrrhizae→Cortex Moutan Radicis,Poria(Indian Bread with Pine)→Poria(Indian Bread),Spica Prunellae→Rhizoma Rehmanniae glutinosae;there were 11 couplet medicines(3 medicines)in association rules with reliability>70%and support>10%,such as Poria(Indian Bread with Pine)→Radix Polygalae,Poria(Indian Bread),Spica Prunellae→Fructus Schisandrae Chinensis,Rhizoma Rehmanniae glutinosae,etc.Conclusion:Professor Fang Zhaohui′s academic thoughts on the treatment of hyperthyroidism with liver qi depression and spleen deficiency syndrome mostly involves the use of Chinese herbs with mild nature for soothing the liver and strengthening the spleen,clearing heat and calming the mind.