益气活络生肌汤对气虚血瘀型糖尿病足患者的影响

Effect of Yiqi Huoluo Shengji Decoction on diabetic foot patients with qi deficiency and blood stasis type

目的观察益气活络生肌汤对气虚血瘀型糖尿病足患者的影响。方法选取江苏省连云港市第一人民医院2020年2月至2021年8月收治的124例糖尿病足患者为研究对象,依据随机数字表法分为对照组、研究组,每组62例。对照组在常规治疗的基础给予负压封闭引流治疗,研究组在对照组的基础上给予益气活络生肌汤,两组均持续治疗8周。比较两组中医症状评分、临床疗效;统计两组创面愈合、周围神经感觉阈值、足背血流变化情况;记录两组治疗期间不良事件发生情况。结果治疗后,两组主症、次症中医证候评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组疗效优于对照组,差异有统计学意义(P<0.05)。研究组足部溃疡肉芽组织出现时间、创面愈合时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组周围神经感觉阈值低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血管内径、血流速度、搏动指数均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。两组不良事件总发生率比较,差异无统计学意义(P>0.05)。结论益气活络生肌汤治疗气虚血瘀型糖尿病足患者可增强治疗效果,加速创面愈合,改善周围神经感觉功能及血液循环,且安全性良好。

Objective To observe the effect of Yiqi Huoluo Shengji Decoction on diabetic foot patients with qi deficiency and blood stasis type.Methods A total of 124 diabetic foot patients admitted to the First People’s Hospital of Lianyungang of Jiangsu Province from February 2020 to August 2021 were selected as the research subjects.They were randomly divided into control group and study group according to the random number table method,with 62 cases in each group.The control group was given vacuum sealing drainage treatment on the basis of conventional treatment,and study group was given Yiqi Huoluo Shengji Decoction on the basis of control group.Both groups were treated for eight weeks.The traditional Chinese medicine symptom scores and clinical efficacy of two groups were compared,the changes of wound healing,peripheral nerve sensory threshold,and dorsum of foot blood flow between two groups were recorded;the occurrence of adverse events during treatment in two groups was recorded.Results After treatment,the traditional Chinese medicine syndrome scores of the main symptom and secondary symptom in both groups were lower than those before treatment,and those in study group was lower than those in control group,and the differences were statistically significant,(P<0.05).The curative effect of study group was better than that of control group,and the difference was statistically significant(P<0.05).The appearance time of foot ulcer granulation tissue and wound healing time in study group were shorter than those in control group(P<0.05).After treatment,the peripheral nerve sensory threshold in two groups was lower than that before treatment,that of study group was lower than that of control group,and the differences were statistically significant(P<0.05).After treatment,inner diameter of blood vessels,blood flow velocity,and pulsatility index in both groups were higher than those before treatment,and those in study group were higher than those in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse events between two groups(P>0.05).Conclusion Yiqi Huoluo Shengji Decoction can enhance the therapeutic effect,accelerate wound healing,and improve peripheral nerve sensory function and blood circulation in patients with diabetic foot due to qi deficiency and blood stasis,with good safety.