中医药防治银屑病的机制研究进展

Mechanism of Traditional Chinese Medicine in the Prevention and Treatment of Psoriasis:A Review

银屑病是一种临床常见的慢性炎症性皮肤病,其病因复杂多样,发病机制目前尚不明确。中医认为银屑病发病有内外因之分,外因如外感风、寒、湿、热、虫等邪气,导致气血阻滞,皮肤失养而发病;内外因如风湿毒气袭表,血分热燥,血燥难荣或素体血虚,外感风燥之邪,合而致病。近现代医家多从血分认识,有血热、血虚、血瘀、血燥之分。现代医学则认为与遗传、免疫、感染等因素相关,其机制研究也紧紧围绕基因遗传易感、免疫系统紊乱、病菌感染等方面。目前临床上疗法多样,主要有系统治疗、局部外用药物等。而中医药治疗银屑病常采用中药内服或外用、传统疗法等,作用以调控体内免疫系统、基因靶点及抗氧化等为主,安全性较高、不良反应少。目前,中医药治疗银屑病的研究机制虽已经逐渐深化,但关于中医药防治银屑病作用机制的详尽整理尚少。该文基于银屑病发病的中西医研究,对中医药防治银屑病的机制进行综述,提供较为全面的临床与实验研究认识,为进一步深入探讨银屑病的发病、治疗及相应的机制研究提供参考。

Psoriasis is a common clinical chronic inflammatory skin disease with a complex and diverse etiology and unrevealed pathogenesis.In traditional Chinese medicine(TCM),psoriasis is caused by internal and external factors.To be specific,external factors such as external wind,cold,dampness,heat,insects,and other pathogenic factors can result in Qi obstruction,blood stasis,and loss of nourishment in the skin,and internal and external factors such as wind,dampness,and toxic qi attacking the exterior,heat and dryness in the blood aspect,difficulty in flourishing due to blood dryness,and blood deficiency in the body,combined with external contraction of wind and dryness trigger the disease.Modern doctors have conducted research from the blood aspect,including blood heat,blood deficiency,blood stasis,and blood dryness.Modern medicine believes that it is related to genetics,immunity,infection,and other factors,and the research on its mechanism focuses on genetic susceptibility,immune system disorder,bacterial infection,and other aspects.At present,various clinical therapies are available,mainly including systematic treatment and local external application of drugs.While treating psoriasis,TCM mainly employs oral administration or external application of Chinese medicine and traditional therapies to regulate the immune system and gene targets and resist oxidation,with high safety and few adverse reactions.At present,although the research on the mechanism of TCM in the treatment of psoriasis has been gradually deepened,there are few detailed summaries on the mechanism of TCM in the prevention and treatment of psoriasis.Based on the research on TCM and western medicine in the treatment of psoriasis,this paper reviewed the mechanism of TCM in the prevention and treatment of psoriasis and proposed a comprehensive clinical and experimental research profile,aiming to provide references for further exploring the pathogenesis,treatment,and corresponding mechanism of psoriasis.