植物合成生物学领域发展态势分析

Development Trend in the Field of Plant Synthetic Biology

植物合成生物学为解决农作物育种及品质改良等重要农业问题带来新机遇。为了使相关科研和管理人员及时了解植物合成生物学的研究进展、把握领域科技前沿、有效开展科研合作、优化研究布局,从文献计量角度分析合成生物学的发展态势。基于Web of Science核心集检索到2000—2020年研究文献97551篇。计量分析结果表明,植物合成生物学领域论文呈现稳定增长趋势,中国学者发表的论文数量及总被引频次位居前列。通过对高被引文献以及文献主题聚类分析可知,重要作用元件如转录因子的调控机制、标准化的遗传元件如启动子、功能基因的挖掘和鉴定、植物天然产物合成与代谢通路的解析、基因编辑技术/多组学分析技术等关键技术是本领域的重要主题内容,将持续推动本领域的创新发展。此外,对比分析了国内外合成生物学的资助及研究布局,针对当前我国在植物合成生物学领域的资助现状提出展望,加强国家顶层设计,加大植物合成生物领域的资助。

Plant synthetic biology brings new opportunities for solving important agricultural problems such as crop breeding and quality improvement. In order to enable researchers and administrators to timely understand of the research progress in plant synthetic biology,grasp the frontiers of science and technology in the field,effectively carry out scientific research cooperation,and optimize the layout of scientific research,this study analyzed the development trend of plant synthetic biology in China from the perspective of literature. Based on constructed retrieval strategy,97 551research papers(from 2000 to 2021)were searched from the Web of Science core set. The quantitative indexes reflected the quantity trend of papers published,the quantity and distribution characteristics of scientific research subjects,the content and evolution characteristics of literature topics. The results of indexes analysis showed that the number of papers published by Chinese scholars and the frequency of their citations were in the leading position in the world.According to the topic cluster analysis of the highly cited literature and the subject of the literature,it showed that the regulation mechanism of important functional elements such as transcription factors,the excavation and identification of standardized genetic elements such as promoters,functional genes,the analysis of the synthetic and metabolic pathways of natural plant products,key technologies such as gene editing and multi-group analysis were the important contents of this field,and would continue to drive innovation in this area. In addition,the funding and research layout of synthetic biology at home and abroad were compared and analyzed. Based on the current situation of funding in the field of plant synthetic biology in China,the prospect of strengthening national top-level design was put forward,with funding to be increased for plant synthetic biology.