原位监测并调控局部活性氧水平促进创面修复

In situ monitoring and regulation of local reactive oxygen species levels to promote wound repair

局部氧化应激、炎症反应是创面修复的重要环节,决定着创面修复进程、结局与质量。活性氧是反映机体氧化应激与炎症反应状态的重要指标之一,被认为是创面炎症调控的理想靶标。近年来,随着纳米医学的快速发展,通过学科间交叉融合,本课题组和其他课题组成功研制出多种活性氧诊疗制剂,以实时监测和调控创面活性氧水平,最终达到提高创面修复速度、改善创面修复质量的目的,从而为创面局部炎症反应诊疗提供新策略和新方向。该文分别就活性氧作为创面局部炎症反应的调控靶标、活性氧的原位监测及活性氧的精准调控做一总结。

Local oxidative stress and inflammatory response are the essential procedures in wound repair,which determine the progress,prognosis,and quality of wound repair.Reactive oxygen species is one of the important indexes reflecting oxidative stress and inflammatory response of body,which is considered as a promising target to be regulated in wound inflammation.Recently,with the rapid development of nanomedicine,our research group and other research groups have successfully developed various diagnosis and treatment reagents for reactive oxygen species through interdisciplinary integration,to monitor and regulate reactive oxygen species in wounds in real time,and to finally achieve the goal of improving the speed and quality of wound repair,thus providing a new strategy and direction for the diagnosis and treatment of local inflammatory response in wounds.This article summarizes reactive oxygen species as the regulatory target of local inflammatory response in wounds,in situ monitoring and precise regulation of reactive oxygen species.