基于组织工程新技术构建理想体外瘢痕模型的研究进展

Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology

瘢痕的形成给患者造成巨大的经济负担和严重的心理阴影。尽管目前用于瘢痕治疗的手段趋于多样化,但是能够真正实现人体皮肤损伤后的“完美愈合”或是“无瘢痕愈合”的治疗方法相当匮乏。随着组织工程技术在医学研究中的广泛应用,诸如生物三维打印、类器官培养和器官芯片技术等新技术不断涌现,基于这些新技术构建的体外疾病模型也展现出比以往传统动物疾病模型更大的优势。该文介绍了类器官培养、生物三维打印、器官芯片技术等目前在皮肤组织工程中应用的热点技术,重点总结了构建理想的体外瘢痕模型需把握的3个关键要素,并结合该研究团队长期从事皮肤组织修复与再生研究的经验,对未来构建理想体外瘢痕模型进行展望。

The scar brings a huge economic burden and creates a serious psychological shadow for patients.Although the current methods for scar treatment tend to be diversified,the treatment method that can truly achieve the goal of"perfect healing"or"scarless healing"after human skin injury is quite scarce.With the wide application of tissue engineering technologies in medicine research,technologies such as three-dimensional bioprinting,organoid culture,and organ chip technologies are constantly emerging.Disease models in vitro based on these innovative technologies showed more advantages than traditional animal disease models.The article introduces the current hotspot technologies in skin tissue engineering such as organoid culture,three-dimensional bioprinting,and organ chip technologies,focuses on summarizing the three key elements to be mastered for constructing an ideal scar model in vitro,and puts forward the future prospect of constructing an ideal scar model in vitro based on our research team's long-term experience in skin tissue repair and regeneration research.