烧伤水疱液相关研究进展

Research advances on burn blister fluid

烧伤常导致受损组织产生大量渗出物,并在创面形成水疱,而烧伤水疱液内含有大量与创面愈合相关的分子,可反映烧伤创面局部组织微环境状态。解析烧伤水疱液中细胞成分、信号介质和蛋白质分子等相关信息有助于了解烧伤创面局部反应和组织微环境,进而助力临床烧伤救治。该文通过解读烧伤水疱液产生机制,探讨烧伤水疱液在创面评估中的作用,并综合烧伤水疱液在蛋白质组学、代谢组学、细胞成分、药代动力学4个方向的研究进展,提出对烧伤水疱液研究的思考与展望,以期为临床烧伤创面评估及治疗提供助力,也为烧伤水疱液的后续研究提供思路。

Burns often cause the damaged tissue to produce a large amount of exudate and the formation of blisters on the wound.The burn blister fluid contains a large number of molecules related to wound healing,which can reflect the state of local tissue microenvironment of the burn wound.Analyzing relevant information such as cellular components,signal mediators,and protein molecules in burn blister fluid is helpful to understand the local reaction and tissue microenvironment of burn wounds,and then help clinical burn treatment.In this article,by understanding the production mechanism of burn blister fluid,discussing its role in wound evaluation,and integrating the research progress of burn blister fluid in proteomics,metabolomics,cellular components,and pharmacokinetics,we propose our thoughts and prospects on the research of burn blister fluid,in order to provide assistance for clinical evaluation and treatment of burn wounds,and also provide idea for the follow-up study of burn blister fluid.