摘要
慢性肾脏病一直以来是世界范围内的公共卫生问题,一旦错过早期干预期,进入终末期肾脏病只能行肾脏替代治疗来维持生存。槲皮素是一种植物类黄酮,槲皮素及其衍生物具有抗氧化、抗炎、抗菌、抗凋亡、抗纤维化等作用。槲皮素及其衍生物槲皮素3-O-葡萄糖苷酸、二氢槲皮素能够抑制氧化应激、抑制炎症反应、抑制纤维化、抑制细胞凋亡、调节肠道菌群、预防造影剂肾病,在保护肾脏方面发挥重要作用。对槲皮素及其衍生物治疗慢性肾脏病的作用机制进行综述,希望为临床用药提供参考。
Chronic kidney disease has always been a worldwide public health problem.If chronic kidney disease misses the early intervention period and enters end-stage renal disease,only renal replacement therapy can be used to maintain survival.Quercetin is a kind of natural flavonoid,and quercetin and its derivatives have antioxidant,anti-inflammatory,antibacterial,anti-apoptotic,and antifibrotic effects.Quercetin and its derivatives quercetin 3-O-glucuronide and dihydroquercetin can inhibit oxidative stress,inhibit inflammatory response,inhibit fibrosis,inhibit apoptosis,regulate intestinal flora,and prevent contrast Nephropathy,and it also plays an important role in protecting the kidneys.This article reviews the mechanism of quercetin and its derivatives in treatment of chronic kidney disease,hoping to provide a reference for clinical practice.
作者
相学梅
李宜航
牟曾熠
李志明
XIANG Xue-mei;LI Yi-hang;MOU Zeng-yi;LI Zhi-ming(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Department of Nephrology,First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《现代药物与临床》
CAS
2022年第9期2148-2154,共7页
Drugs & Clinic
基金
辽宁省教育厅科学研究经费项目(L202060)。
关键词
槲皮素
二氢槲皮素
慢性肾脏病
氧化应激
炎症反应
纤维化
细胞凋亡
quercetin
dihydroquercetin
chronic kidney disease
oxidative stress
inflammatory response
fibrosis
apoptosis
