醒脑静治疗成人颅内化脓性脑膜炎临床疗效观察

Clinical Observation of Xingnaojing in the treatment of Adult Intracranial Suppurative Meningitis

目的:探讨醒脑静治疗成人颅内化脓性脑膜炎的临床疗效。方法:选取本院于2019年12月—2020年12月收治的70例颅内化脓性脑膜炎患者为研究对象,使用随机数字表法将其均分为对照组和研究组,每组35例。对照组进行常规治疗,研究组在对照组基础上进行醒脑静治疗。比较两组发热持续时间和GCS评分,治疗前后肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶(NSE)、乳酸脱氢酶(LDH)水平及临床疗效。结果:研究组发热持续时间短于对照组,14d GCS评分低于对照组(P<0.05)。两组治疗后TNF-α、NSE、LDH水平低于治疗前,且研究组低于对照组(P<0.05)。研究组治疗有效率为91.4%,高于对照组的71.4%(P<0.05)。结论:醒脑静治疗成人颅内化脓性脑膜炎的临床疗效显著,能有效缩短患者的退热时间及炎性因子水平,进而有效降低GCS评分,促进其意识清醒,有利于提高预后。

Objective:To explore the clinical efficacy of Xingnaojing in the treatment of adult intracranial suppurative meningitis.Methods:A total of 70 patients with intracranial purulent meningitis admitted to our hospital from December 2019 to December 2020 were selected as the research objects.They were divided into control group and study group by random number table method,with 35 cases in each group.The control group received routine treatment,and the study group received Xingnaojing treatment on the basis of the control group.The duration of fever,GCS score,levels of tumor necrosis factor-α(TNF-α),neuron-specific enolase(NSE)and lactate dehydrogenase(LDH)before and after treatment and clinical efficacy were compared between the two groups.Results:The duration of fever in the study group was shorter than that in the control group,and the 14 dGCS score was lower than that in the control group(P<0.05).The levels of TNF-α,NSE and LDH in the two groups after treatment were lower than those before treatment,and those in the study group were lower than the control group(P<0.05).The effective rate of the study group was 91.4%,which was higher than 71.4%of the control group(P<0.05).Conclusion:Xingnaojing has a significant clinical effect in the treatment of adult intracranial suppurative meningitis,which can effectively shorten the antipyretic time and the level of inflammatory factors,effectively reduce the GCS score,promote their consciousness and improve the prognosis.