骨代谢标志物在儿童生长发育相关疾病中应用的研究进展

Research advances in the application of bone metabolic markers in children′s diseases associated with growth and development

近年来, 佝偻病、肥胖症、矮小症、性早熟等儿童生长发育相关疾病发病率逐年上升, 这类疾病的发生发展往往与儿童营养不良及内分泌紊乱密切相关。大量研究表明骨骼不仅是人体的结构支架, 也是重要的内分泌器官和激素靶器官。作为与骨形成和骨吸收紧密联系的一系列物质, 骨代谢标志物水平已被证实在多种儿童生长发育疾病进程中发生变化。本文通过对骨代谢标志物的特点、分类及其在儿童生长发育相关疾病中的应用进行阐述, 以期为儿童生长发育疾病的预防、早期诊断及疗效监测提供依据。

The incidence of children′s growth and development diseases such as rickets,obesity,dwarfism and precocious puberty has increased year by year recently.The occurrence and development of these diseases are often closely related to children′s malnutrition and endocrine disorders.Plenty of studies have indicated that bone is not only the structural scaffold of human body,but also an important endocrine and hormone target organ.As a series of substances closely related to bone formation and bone resorption,the levels of bone metabolic markers have been confirmed to change in the course of many children′s growth and development diseases.The characteristics,classification and application of bone metabolism markers in children′s growth and development related diseases was summarized and commented in this article in order to provide reference for the prevention,early diagnosis and treatment effect monitoring of children′s growth and development diseases.