强迫症认知行为治疗疗效相关的生物标志物研究进展

Research progress of biomarkers related to the efficacy of cognitive-behavioral therapy for obsessive-compulsive disorder

强迫症是一种常见的慢性波动性精神障碍。国内外指南推荐认知行为治疗(cognitive behavior therapy,CBT)是强迫症的一线治疗手段,其疗效已获得大量循证医学证据支持。尽管如此,仍有部分强迫症患者未从中获益,而目前临床上尚缺少疗效预测的客观指标。近年来,随着可用于诊疗预测的技术方法迅速发展,探寻强迫症CBT疗效相关的生物标志物逐渐受到各界关注。本文拟从心理生理学、遗传学及神经影像学等方面对强迫症CBT疗效相关研究现状进行综述,以期为强迫症个体化精准治疗提供初步依据。

Obsessive-compulsive disorder is a common chronic fluctuating mental disorder.Domestic and foreign guidelines recommend cognitive behavior therapy(CBT)as the first-line treatment for obsessive-compulsive disorder.The efficacy of CBT has support from a large amount of evidence-based medical evidence.Nevertheless,some patients with obsessive-compulsive disorder have not benefited from it,and there is still a lack of objective indicators for predicting the curative effect in clinic.In recent years,with the rapid development of techniques and methods that can be used for diagnosis and treatment prediction,exploring the biomarkers related to the efficacy of CBT in obsessive-compulsive disorder has attracted more and more attention.This article reviews the current research on the efficacy of CBT in obsessive-compulsive disorder from the aspects of psychophysiology,genetics,and neuroimaging,in order to provide a preliminary basis for individual and accurate treatment of obsessive-compulsive disorder.