保留比值受损肺功能人群研究进展

Progress in preserved ratio impaired spirometry

保留比值受损肺功能(PRISm)是指一秒率(FEV1/FVC)正常但出现第一秒用力呼气容积(FEV1)降低的肺功能测定模式。PRISm在人群中普遍存在, 但在目前的研究中被低估。欧美队列研究发现PRISm人群的慢阻肺发生风险、心血管相关死亡风险和全因死亡风险较肺功能正常人群显著增加, 其可能是慢阻肺前期人群之一, 因此早期发现和防治PRISm至关重要。本文就目前PRISm研究进展进行综述, 以增加对PRISm的认识, 更好地为PRISm人群提供综合全面的评估和管理。

Preserved ratio impaired spirometry(PRISm)refers to the mode of a decrease in forced expiratory volume in 1 second(FEV1)while the FEV1/forced vital capacity(FVC)remains constant.PRISm was prevalent in the study population,but it is underreported in the current research.The cohort studies in European-American have found that the PRISm has a higher risk of developing chronic obstructive pulmonary disease(COPD),cardiovascular-related deaths and all-causes death than the normal lung function.PRISm may be one of the pre-COPD population,so early detection and prevention are crucial.In this review,we summarized the recent advances in the research of PRISm with the aim to increase understanding of PRISm,and to provide comprehensive evaluation and management for PRISm population.