低分子肝素钙改良式注射方法应用于肺栓塞患者中的临床价值

Clinical Value of Modified Low Molecular Weight Heparin Calcium Injection in Patients with Pulmonary Embolism

目的:探讨低分子肝素钙改良式注射方法应用于肺栓塞患者中的临床价值。方法:选取2021年1月-2022年1月在宜春市人民医院接受低分子肝素钙治疗的肺栓塞患者64例。按随机数字表法将患者分为两组。对照组32例通过传统方法注射低分子肝素钙,观察组32例通过改良方式注射低分子肝素钙。比较两组皮下出血发生情况、疼痛情况、凝血功能及预后情况。结果:观察组皮下出血发生率为9.38%,低于对照组的31.25%(P<0.05)。最后一次注射后12、24、48 h时,观察组NRS评分均低于对照组(P<0.05)。治疗后,观察组血浆D-二聚体(D-D)水平低于对照组,血浆活化部分凝血酶时间(APTT)、血浆凝血酶原时间(PT)均长于对照组(P<0.05)。治疗后,观察组6分钟步行试验距离长于对照组,Wells评分低于对照组(P<0.05)。结论:低分子肝素钙改良式注射方法治疗肺栓塞可有效减少皮下出血的发生,减轻疼痛程度,并进一步改善患者凝血功能及预后。

Objective:To investigate the clinical value of the modified Low Molecular Weight Heparin Calcium injection in patients with pulmonary embolism.Method:A total of 64 patients with pulmonary embolism who received Low Molecular Weight Heparin Calcium therapy in Yichun People’s Hospital from January 2021 to January 2022 were selected,according to the random number table method,they were randomly divided into two groups.32 cases in the control group were injected with Low Molecular Weight Heparin Calcium by the traditional method,and 32 cases in the observation group were injected with Low Molecular Weight Heparin Calcium by the improved method.The incidence of subcutaneous hemorrhage,pain,coagulation function and prognosis were compared between the two groups.Result:The incidence of subcutaneous hemorrhage in the observation group was 9.38%,which was lower than 31.25%in the control group(P<0.05).At 12,24,and 48 h after the last injection,the NRS scores of the observation group were lower than those of the control group(P<0.05).After treatment,the level of plasma D-dimer(D-D)in the observation group was lower than that of the control group,and the plasma activated partial thrombin time(APTT)and plasma prothrombin time(PT)of the observation group were longer than those of the control group(P<0.05).After treatment,the 6 min walking distance of the observation group was longer than that of the control group,and the Wells score of the observation group was lower than that of the control group(P<0.05).Conclusion:Modified injection of Low Molecular Weight Heparin Calcium in the treatment of pulmonary embolism can effectively reduce the occurrence of subcutaneous hemorrhage,relieve pain,and further improve the coagulation function and prognosis of patients.