小儿支原体肺炎体液免疫功能与hs-CRP检验的临床价值

Clinical Value of Humoral Immune Function and hs-CRP Test in Children with Mycoplasma Pneumonia

目的探讨体液免疫功能与超敏-C反应蛋白(high sensitivity C reactive protein,hs-CRP)检验在小儿支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)中的效果。方法选取2019年1月-2021年8月新疆生产建设兵团第四师医院收治的80例MPP患儿为研究对象,按病情的严重程度分为重症组(40例)与轻症组(40例),同时选取同期体检健康的40名儿童为对照组。给予所有研究对象体液免疫功能与hs-CRP检验,比较3组的检验结果。结果重症组的免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平分别为(11.89±2.36)g/L、(2.68±0.75)g/L,高于轻症组[(9.58±1.49)g/L、(1.63±0.58)g/L]与对照组[(7.36±1.21)g/L、(1.05±0.26)g/L],免疫球蛋白A(IgA)为(1.13±0.34)g/L,低于轻症组[(1.35±0.48)g/L]与对照组[(1.63±0.54)g/L],差异有统计学意义(t=5.235、7.004、10.823、12.987、2.366、4.956,P<0.05);重症组的hs-CRP水平为(43.25±4.36)mg/L,均高于轻症组(21.48±2.57)mg/L与对照组(7.85±1.26)mg/L,差异有统计学意义(t=27.205、49.332,P<0.05)。结论体液免疫功能与hs-CRP检验在MPP患儿诊断中价值较高,利于医师了解患儿病情,为选择科学的治疗方案奠定良好基础。

Objective To investigate the effect of humoral immune function and high sensitivity C reactive protein(hs CRP)test in children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 80 children with MPP who were admitted to the Fourth Division Hospital of Xinjiang Production and Construction Corps from January 2019 to August 2021 were selected as the research objects,and were divided into a severe group(40 cases)and a mild group(40 cases)according to the severity of the disease.At the same time,40 healthy children with physical examination during the same period were selected as the control group.All subjects were tested for humoral immune function and hs-CRP,and the test results of the three groups were compared.Results The levels of immunoglobulin G(IgG)and immunoglobulin M(IgM)in the severe group were(11.89±2.36)g/L and(2.68±0.75)g/L,respectively,higher than the mild group[(9.58±1.49)g/L,(1.63±0.58)g/L]and the control group[(7.36±1.21)g/L,(1.05±0.26)g/L].Immunoglobulin A(IgA)was(1.13±0.34)g/L,which was lower than the mild group[(1.35±0.48)g/L]and the control group[(1.63±0.54)g/L],the difference was statistically significant(t=5.235,7.004,10.823,12.987,2.366,4.956,P<0.05).The hs CRP level in the severe group was(43.25±4.36)mg/L,both were higher than the mild group(21.48±2.57)mg/L and the control group(7.85±1.26)mg/L,the difference was statistically significant(t=27.205,49.332,P<0.05).Conclusion The detection of humoral immune function and hs-CRP is of high value in the diagnosis of children with MPP,which is helpful for doctors to understand the condition of children,and lays a good foundation for choosing a scientific treatment plan,which is worthy of vigorous clinical promotion.