局部晚期宫颈癌同步放化疗的研究进展

Research Progress of Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer

宫颈癌属于女性人群的生殖系统恶性肿瘤,超过半数的患者确诊后病情即发展为晚期。临床研究表示:通过调强放疗、三维后装放疗的临床疗效高于传统放疗,该方法也成晚期宫颈癌患者的主要放疗方法。宫颈癌通过单纯放疗治疗,临床较差,而通过放化疗方法治疗患者,更能够提升临床效果。目前,临床中一般会选择通过铂类放化疗治疗患者,但诱导化疗、辅助化疗及同步放化疗的不同组合治疗方式的临床价值尚待明确。对于放疗资源受限的地区,术前新辅助化疗可以作为补充治疗。正电子发射断层显像术、计算机体层摄影能够准确观察腹主动脉旁淋巴结,评估价值较高,能够为患者的个体化治疗方案的制定提供依据。本文作者就局部晚期宫颈癌的放疗、化疗的研究进展作出综述。

Cervical cancer belongs to the female reproductive system malignant tumor,and more than half of the patients develop advanced disease after diagnosis.Clinical studies show that the clinical efficacy of intensity-modulated radiotherapy and three-dimensional afterload radiotherapy is higher than that of traditional radiotherapy.This method has also become the main radiotherapy method for patients with advanced cervical cancer.Cervical cancer is treated with radiotherapy alone,and the clinical effect is poor,while the treatment of patients with radiotherapy and chemotherapy can improve the clinical effect.At present,patients are generally treated with platinum-based chemoradiotherapy in clinical practice.However,the clinical value of different combinations of induction chemotherapy,adjuvant chemotherapy,and concurrent chemoradiotherapy remains to be determined.For regions with limited radiotherapy resources,preoperative neoadjuvant chemotherapy can be used as a complementary treatment.Positron emission tomography and computed tomography can accurately observe para-aortic lymph nodes and have high evaluation value,which can provide a basis for the formulation of individualized treatment plans for patients.In this article,the author reviews the research progress of radiotherapy and chemotherapy for locally advanced cervical cancer.