补肾化痰活血方联合针灸对多囊卵巢综合征患者促排卵功能及性激素水平的影响

Effect of Bushen Huatan Huoxue Decoction combined with acupuncture on ovulation induction function and sex hormone levels in patients with polycystic ovary syndrome

[目的]探讨补肾化痰活血方联合针灸治疗多囊卵巢综合征(PCOS)效果。[方法]选取河北省沧州中西医结合医院2020年6月—2021年6月收治的130例PCOS患者为研究对象,采用随机数字表法分为A组和B组,各65例。A组患者给予枸橼酸氯米芬胶囊,B组患者加服补肾化痰活血汤联合针灸。治疗过程中A组脱落2例,B组脱落2例,每组共有63例进入统计学分析。于治疗前后检测患者卵泡刺激素(FSH)、黄体生成素(LH)、总睾酮(T)、雌二醇(E2)水平和排卵期子宫内膜厚度,采用中医证候积分对患者症状进行评分,统计患者排卵率、妊娠率和不良反应发生率。[结果]治疗后,两组LH和T水平、经期腹痛、头晕耳鸣、腰膝酸疼和性欲淡漠评分均降低且B组低于A组,差异具有统计学意义(P<0.05);治疗后,两组E2水平和子宫内膜厚度均增加且B组E2水平高于A组,差异具有统计学意义(P<0.05);B组排卵率和妊娠率高于A组,差异具有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。[结论]补肾化痰活血方联合针灸可有效改善PCOS患者性激素水平,缓解临床症状,提高排卵率和妊娠率,安全有效。

[Objective]To explore the effect of Bushen Huatan Huoxue Decoction combined with acupuncture in the treatment of polycystic ovarian syndrome(PCOS).[Methods]The124 patients with PCOS admitted to our hospital from June 2020 to June 2021 were selected as the research objects.They were divided into the group A and the group B by a random number table method and double blind method,with 65 cases in each group.With clomiphene citrate capsules,the group B was treated with Bushen Huatan Huoxue Decoction combined with acupuncture and moxibustion.During the treatment,2 cases in group A were fell off,and 2 cases in group B were fell off.A total of 63 cases in each group entered into statistical analysis.The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),total testosterone(T),estradiol(E2)and endometrial thickness during ovulation were measured before and after treatment,and the symptoms of the patients were scored by the traditional Chinese medicine(TCM)syndrome score,statistics of patients’ovulation rate,pregnancy rate and incidence of adverse reactions.[Results]After treatment,the scores of LH and T levels,menstrual abdominal pain,dizziness,tinnitus,waist and knee pain,and apathy in the two groups were reduced,and the group B was lower than the group A(P<0.05),and the E2 level and endometrial thickness were both increased and the E2 level of the group B was higher than that of the group A(P<0.05).The ovulation rate and pregnancy rate of the group B were higher than those of the group A(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).[Conclusion]Bushen Huatan Huoxue Decoction combined with acupuncture can effectively improve the level of sex hormones in patients with PCOS,relieve clinical symptoms,increase ovulation rate and pregnancy rate,safe and effective.