固肾定喘丸联合西药治疗肺肾气虚型支气管哮喘的疗效观察

Clinical Effect of Gushen Dingchuan Pills Combined with Western Medicine on Bronchial Asthma of Lung-Kidney Qi Deficiency Syndrome

目的探讨固肾定喘丸联合西药治疗肺肾气虚型支气管哮喘的疗效观察。方法选取2019年1月—2020年6月期间河南省濮阳市中医医院收治的肺肾气虚型支气管哮喘患者88例作为研究对象,按随机数字表法分为对照组44例和治疗组44例。对照组采用常规西医治疗,治疗组在此基础上加用固肾定喘丸治疗。两组患者治疗4周后。对两组患者临床疗效,治疗前及治疗4周后中医症状(喘息、咳嗽及哮鸣音)积分、哮喘控制测试评分、肺功能指标[第1秒用力肺活量占预计值百分比(Orced expiratory volume in one second Percentage,FEV1%)和第1秒用力肺活量占用力肺活量的比值(FEV1/Forced vital capacity,FEV1/FVC)]及炎性因子[白细胞介素-4(Interleukin-4,IL-4)和白细胞介素-8(Interleukin-8,IL-8)]水平进行分析和比较。结果治疗后治疗组总有效率97.72%与对照组84.09%比较,差异有统计学意义(P<0.05)。治疗4周后,两组患者喘息、咳嗽及哮鸣音积分较治疗前均降低,差异有统计学意义(P<0.05);且治疗组喘息、咳嗽及哮鸣音积分与对照组比较明显降低,差异有统计学意义(P<0.05)。治疗4周后,两组ACT评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组较对照组明显升高,差异有统计学意义(P<0.05);治疗4周后两组患者FEV1、FEV1/FVC均较治疗前升高,差异有统计学意义(P<0.05);且治疗组FEV1、FEV1/FVC与对照组比较明显升高,差异有统计学意义(P<0.05)。治疗4周后两组患者IL-4、IL-8水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组IL-4、IL-8水平与对照组比较明显降低,差异有统计学意义(P<0.05)。结论固肾定喘丸能明显提升肺肾气虚型支气管哮喘的治疗效果,改善患者临床症状和肺功能,减轻炎症反应。

Objective To explore the clinical effect of Gushen Dingchuan Pills combined with western medicine onbronchial asthma of the lung-kidney qi deficiency syndrome.Methods A total of 88 patients with bronchial asthma of the lung-kidney qi deficiency syndrome who were treated in Chinese Medicine Hospital of Puyang from January 2019 to June 2020 were randomized into thecontrol group(n=44)and treatment group(n=44)with the random number table method.The control group received routine western medicine therapy,and treatment group theGushen Dingchuan Pills and routine western medicine therapy.The treatment lasted 4 weeks for patients in both groups.The clinical efficacy,and thetraditional Chinese medicine(TCM)symptom(wheezing,coughing,and wheezing rale)score,asthma control test(ACT)score,pulmonary function indexes[reduced forced expiratory volume in 1 second percentage(FEV1%),FEV1/forced vital capacity(FEV1/FVC)],and levels of inflammatory factors[interleukin-4(IL-4),interleukin-8(IL-8)]before treatment and after 4 weeks of treatment were analyzed and compared between the two groups.Results The total effective rate in the treatment group(97.72%)was higher than that in the control group(84.09%)(P<0.05).After 4 weeks of treatment,the scores of wheezing,coughing,and wheezing rale were lower than those before treatment in both groups(P<0.05)and lower in the treatment groupthanin the control group(P<0.05).The ACT score of the treatment group washigher than that of the control group(P<0.05).After 4 weeks of treatment,FEV1 and FEV1/FVC were higher than those before treatment in both groups(P<0.05)and were higher in the treatment group than in the control group(P<0.05).After 4 weeks of treatment,the levels of IL-4 and IL-8 in the two groups werelower than those before treatment(P<0.05),and the levels in thetreatment group were lower than those in the control group(P<0.05).Conclusion Gushen Dingchuan Pills can significantly improve the efficacy on bronchial asthma of the lung-kidney qi deficiency syndrome,as manifested by the alleviation of clinical symptoms andinflammatory reaction and improvement of lung function.