急性胰腺炎相关性腹腔积液研究进展

Advances in research and clinical diagnosis and treatment of pancreatitis associated ascitic fluid

急性胰腺炎起病急、并发症多,是临床常见的急腹症。其中,重型急性胰腺炎常在病程早期出现胰腺炎相关性腹腔积液,也称为胰源性腹腔积液。目前,关于胰源性腹腔积液的研究已取得较大的进展。在各种病因诱导的急性胰腺炎病程早期,由于胰腺局部的炎症及继发扩大化的瀑布式炎症反应,引发胰腺及胰周组织渗出,以及炎症因子释放共同参与形成胰腺炎相关性腹腔积液。由于含有大量有害因子,胰腺炎相关性腹腔积液可经多种通路造成机体多器官功能损害,从而加重病情,这在大量的动物实验中已得到证实。目前已有不少学者强烈推荐通过微创化外科干预来处理胰腺炎相关性腹腔积液,以求改善病人预后。

Acute pancreatitis is character with rapid onset and many complications.It is a common clinical acute abdomen.Among them,severe acute pancreatitis often has pancreatitis associated ascitic fluid(PAAF)in the early course of the disease,which is also called pancreatic ascites.At present,the research on PAAF has made great progress.In the early stages of the course of acute pancreatitis induced by various etiologies,due to the local inflammation of the pancreas and the secondary magnified cascade inflammation,the exudation of pancreas and peripancreatic tissues,and the release of inflammatory factors are jointly involved in the formation of pancreatitis associated ascitic fluid.Due to it contains a large number of harmful factors,pancreatitis associated ascitic fluid can cause damage to multiple organs of the body through a variety of pathways,thereby aggravating the disease,which has been confirmed in a large number of animal experiments.At present,many scholars strongly recommend minimally invasive surgical intervention to treat pancreatitis associated ascitic fluid in order to improve the prognosis of patients.