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人类基因组项目与精准医疗的再思考 被引量:3

Rethinking human genome project and precision medicine
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摘要 近几十年来,伴随着基因组学研究的巨大进步与发展,生物医学领域也随之出现巨大转变,诸多以个体化精准医疗实践为出发点,对基于基因检测、生物标志物筛查和靶向药物开发等研究的投资不断增加。国内外许多学者开始质疑精准医疗是否真的是通往更健康世界的途径,对于精准医疗的投入与成果已经开始产生争论。因此,本文以《人类基因组计划对医学和社会后果》最初的愿景为切入点,探讨该愿景的假设、承诺、限制和可能性,以期为更合理、客观地认识精准医疗提供参考。 The dramatic advances in genomics research in recent decades have raised great expectations for the impact of biomedicine.There has been a growing investment in research based on genetic testing,biomarker screening,and the development of targeted drugs,starting with personalized precision medicine practices.Many scholars at home and abroad have begun to question whether precision medicine is really the way to a healthier world,and the investment and results of precision medicine have been in debate.Therefore,this paper takes the initial vision of the Human Genome Project for Medical and Social Consequences as a starting point to explore its assumptions,promises,limitations and possibilities,with a view to providing a reference for a more reasonable and objective understanding of precision medicine.
作者 杨振宇 辛培源 周帅 包国强 何显力 YANG Zhenyu;XIN Peiyuan;ZHOU Shuai;BAO Guoqiang;HE Xianli(Department of General Surgery,Tangdu Hospital,Air Force Medical University,Xi an 710038,China;No.93721 Hospital of PLA,Shuozhou 038300,China)
出处 《空军军医大学学报》 CAS 2022年第6期774-778,共5页 Journal of Air Force Medical University
基金 国家自然科学基金(81572916)。
关键词 人类基因组计划 精准医疗 基因组学 基因治疗 公共卫生 human genome project precision medicine genomics gene therapy public health
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