柴胡加龙骨牡蛎汤对乳腺癌内分泌治疗后类更年期综合征的疗效

Efficacy of Chaihu plus Longgu Muli Decoction on menopausal-like symptoms after endocrine therapy for breast cancer

目的:探讨柴胡加龙骨牡蛎汤对乳腺癌内分泌治疗后类更年期综合征的临床疗效。方法:通过随机数字表法将患者分为对照组与治疗组,各62例。对照组给予谷维素联合维生素B6片,治疗组予柴胡加龙骨牡蛎汤,观察两组患者的临床疗效。结果:Kupperman评分、中医症状积分、Karnofsky功能状态(Karnofsky performancestatus, K P S)评分及乳腺癌患者生命质量测定量表(Functional Assessment of Cancer Therapy-Breast,FACT-B)评分比较,治疗组均优于对照组,差异有统计学意义(均P<0.05)。两组患者血清性激素水平治疗前后比较,差异无统计学意义(P>0.05)。结论:柴胡加龙骨牡蛎汤可显著改善乳腺癌内分泌治疗后类绝经期综合征,同时对性激素水平无影响,疗效可靠,值得临床推广。

Objective:To investigate the clinical efficacy of Chaihu plus Longgu Muli Decoction on menopausal-like syndrome after breast cancer treatment.Methods:According to the random control method,they were divided into a control group and a treatment group,62 cases in each group.The control group was given oryzanol combined with vitamin B6 tablets,and the treatment group was given Chaihu plus Longgu Muli decoction.After the treatment,the clinical efficacy of the 2 groups was observed.Results:The Kupperman score,traditional Chinese medicine symptom score,Karnofsky performance status(KPS)score,and Functional Assessment of Cancer Therapy-Breast(FACT-B)score in the treatment group were better than those in the control group,and the difference was statistically significant(all P<0.05).There was no significant difference in serum sex hormone levels between the 2 groups before and after the treatment(P>0.05).Conclusion:Chaihu plus Longgu Muli Decoction can significantly improve the menopausal-like syndrome after endocrine therapy for breast cancer and has no effect on sex hormone levels.The curative effect is reliable and worthy of clinical promotion.