髓源性抑制细胞在骨转移中的作用及治疗进展

Advances of role and treatment of myeloid-derived suppressor cells in bone metastases

髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是一种具有免疫抑制功能的未成熟髓样细胞(immature myeloid cells,IMCs),对肿瘤的生长和转移至关重要。MDSCs通过抑制T细胞增殖、抗肿瘤活性及促进调节性T细胞的增殖而发挥其免疫抑制功能。此外,MDSCs还能在骨微环境中通过与破骨细胞、成骨细胞及骨基质细胞等相互作用,促进肿瘤骨转移。因此针对MDSCs的治疗可能为未来改善恶性肿瘤骨转移的预后提供新的药物靶点。

Myeloid-derived suppressor cells(MDSCs), which are essential for tumor growth and metastasis, are immature myeloid cells(IMCs) with immunosuppressive functions. By inhibiting proliferation and antitumor activities of T cells and promoting the proliferation of regulatory T cells, MDSCs can serve their immunosuppressive functions. MDSCs in the bone-metastasis microenvironment interact with osteoclasts and stromal cells, leading to an acceleration of cancer-related bone metastasis. Therefore, the treatment of MDSCs may provide new drug targets for improving the prognosis of bone metastases of malignant tumors in the future.